Hoechst Aktiengesellschaft

Jaromir Komarek

Werner Thorwart

Alfons Soder

Heinz-Joachim Hinze

Werner Mohler

Carl Cartheuser

Manfred Jayme

Ulrich Gebert

Harald Furrer

Kurt Popendiker

Gerhard Munch

Heinz-Gunther Greve

Mario Reiser

Gebert Ulrich

A compound of general formula ##STR1## wherein X represents a radical selected from the group consisting of one of the formulae ##STR2## in which R.sup.1 represents a radical selected from the group

O-[3-(4-Substituted-piperazin-1-yl)-2-hydroxypropyl]-hydroxylamines

Compounds of general formula ##STR1## wherein R.sup.1 represents a radical selected from the group consisting of (a) hydrogen, carboxyl;

Novel O-propyloximes

Compounds of general formula ##STR1## wherein one of the groups R.sub.1 and R.sub.3 is a straight-chain or branched oxoalkyl group consisting from 5 to 8 carbon atoms and the oxygen atom is attached to a non-terminal carbon atom and is separated from the nearest ring nitrogen atom by at least 3 carbon atoms in (.omega.-1)-oxoalkyl groups and by at least 4 carbon atoms in oxoalkyl groups in which the oxygen atom is separated from the terminal carbon atom by more than one carbon atom, R.sub.2 and the other one of groups R.sub.1 and R.sub.3 are straight chain or branched alkyl groups containing from 1 to 12 carbon atoms but wherein that group R.sub.1 or R.sub.3 which is other than an oxoalkyl group may also be hydrogen, one nitrogen-bound substituent being hydrogen or alkyl containing more than 1 carbon atom, and physiologically acceptable acid addition salts thereof, a process for their preparation and pharmaceutical compositions containing said compounds.

Xanthine derivatives

A pharmaceutical composition having as an essential ingredient a compound of the formula ##STR1## wherein one to three of R.sup.1, R.sup.2 and R.sup.3 represent an alkenyl group having from 4 to 8 carbon atoms, the other ones are alkyl having from 1 to 12 carbon atoms, and R.sup.1 may also be hydrogen, the compounds themselves and a process for preparing them.

Pharmaceutical compositions containing xanthines

Compound of the formula ##STR1## wherein one of the groups R.sub.1, R.sub.2 and R.sub.3 is a hydroxyalkyl group containing from 4 to 8 carbon atoms, one of the other two, which may be the same or different, is an alkyl group containing from 2 to 12 carbon atoms and the third one is an alkyl group containing from 1 to 12 carbon atoms or a hydrogen atom, R.sub.2 however being an alkyl or hydroxyalkyl group, at least one of the groups R.sub.1, R.sub.2 and R.sub.3 containing at least 5 carbon atoms, a process for their preparation and a pharmaceutical composition containing said compounds.

Hydroxyhexyl-alkylxanthines and pharmaceutical compositions containing

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Wiesbaden, Germany

Jaromir Komarek