Orion-Yhtyma Oy

Other

Risto Arvo Sakari Lammintausta

Jarmo Sakari Salonen

Arto J Karjalainen

Risto A Lammintausta

Arja Marketta Kalapudas

Reino O Pelkonen

Aire Maria Laine

Marja-Liisa Sodervall

Raimo E Virtanen

Arja L Karjalainen

Maire M Eloranta

Antti S Haapalinna

Hannu T Sipila

Maria-Liisa Sodervall

Aire Marja Laine

##STR1## New compounds of formula (I) wherein R.sub.1 is H, CH.sub.3, OCH.sub.3, NO.sub.2, NH.sub.2, CN, CF.sub.3, CHF.sub.2, CH.sub.2 F or halogen, R.sub.2 is a heterocyclyl radical selected from 1-imidazolyl, triazolyl, tetrazolyl, pyrazolyl, pyrimidinyl, oxazolyl, thiazolyl, isoxazolyl and isothiazolyl, R.sub.3 is H or OH, R.sub.4 is H, R.sub.5 is H or OH; or R.sub.4 is H and R.sub.3 and R.sub.5 combined form a bond; or R.sub.3 is H and R.sub.4 and R.sub.5 combined form .dbd.O; R.sub.6 is methylene, ethylene, --CHOH--, --CH.sub.2 --CHOH--, --CHOH--CH.sub.2 --, --CH.dbd.CH-- or --C(.dbd.O)--; or R.sub.4 is H and R.sub.5 and R.sub.6 combined is .dbd.CH-- or .dbd.CH--CH.sub.2 --; stereoisomers thereof and non-toxic pharmaceutically acceptable acid addition salts thereof exhibit selective aromatase inhibiting properties, compared with their desmolase inhibiting properties. The compounds of the invention are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer or benign prostatic hyperplasia (BPH).

Selective aromatase inhibiting compounds

Selective aromatase inhibiting 4(5)-imidazoles

4(5) substituted imidazoles and their preparation and use

Growing community of inventors

Turku, Finland

Jarmo Sakari Salonen