Glykos Finland Oy

Nexstim Oyj

Suomen Punainen Risti Veripalvelu

Jarmo Laine

Jari Natunen

Tero Satomaa

Heidi Anderson

Maria Blomqvist

Taina Jaatinen

Annamari Heiskanen

Ulla Impola

Anne Olonen

Johanna Nystedt

Anita Laitinen

Juhani Saarinen

Tuomas Neuvonen

Henri Hannula

Gustaf Järnefelt

Milla Mikkola

Sari Tiitinen

Jukka Partanen

Sarl Tiitinen

It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.

Bi-phasic paired pulse transcranial magnetic stimulation

The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods used in connection with the cells in order to avoid alterations of the cell glycosylation by contaminating materials. The invention is further directed to novel stem cells, the glycosylation of which has been specifically altered.

Method for evaluating cell populations

The invention describes methods for production of novel composition of glycans, glycomes, from human multipotent stem cells. The invention is further directed to methods for modifying the glycomes and analysis of the glycomes and the modified glycomes. Furthermore the invention is directed to stem cells carrying the modified glycomes on their surfaces.

Carbohydrate profile compositions from human cells and methods for analysis and modification thereof

The present invention relates to a method of profiling a cell population comprising a step of detecting the presence or absence of at least two biological markers in said cell population, wherein at least one of said markers is a cell surface marker, which is a sialylated N-glycan marker with structure NeuNAc&#x3b1;3Gal, and at least one of said markers is a mRNA marker related to glycoproteins and/or glycosynthase proteins. The invention also relates to method for purification of cord blood cell population and to a complete cell population from cord blood purified by said method.

Method of profiling a cell population

Growing community of inventors

Helsinki, Finland

Jarmo Laine