Leiras Oy

Schering Oy

Santen Oy

Santen Pharmaceutical Co., Ltd.

Jarkko Ruohonen

Harri Jukarainen

Matti Lehtinen

Juha Ala-Sorvari

Tommi Markkula

Olli Aaltonen

Esko Pohjala

Kari Lehmussaari

Timo Reunamaki

Olli Oksala

Anneli Hase

Martti Alkio

Jukka Sepp&auml;l&auml;

Kauko Nieminen

Juhani Lundell

Tapani Suortti

Pirkko Lehtinen

Juba Ala-Sorvari

Klaus Lampi

Markku Peralampi

The invention relates to a method for the preparation of a siloxane-based elastomer composition comprising at least one elastomer, said elastomer composition comprising poly(alkylene oxide) groups present in the elastomer as alkoxy-terminated grafts of polysiloxane units and linked to the polysiloxane units by silicon-carbon bonds wherein at least one vinyl functional polymer component is crosslinked in the presence of a peroxide catalyst.

Method for preparing a siloxane-based elastomer composition

A membrane or matrix for controlling the permeation rate of a drug, where the membrane or matrix includes a siloxane-based elastomer composition which contains at least one elastomer and optionally a non-crosslinked polymer. The elastomer composition includes poly(alkylene oxide) groups, and the poly(alkylene oxide) groups are present as blocks in a chain of the elastomer or the polymer, or as blocks and alkoxy-terminated grafts of polysiloxane units, the blocks or blocks and grafts being linked to the polysiloxane units by silicon-carbon bonds, with at least three blocks being present in the elastomer or polymer chain. Methods for the preparation of the elastomer composition are also disclosed.

Membrane or matrix for controlling the permeation rate of drugs

A device for the controlled release over a prolonged period of time of a drug having antiprogestinic properties, the device including a core containing the drug, optionally a membrane encasing the core, where at least one of the core and membrane, when present, is made of a siloxane-based elastomer composition including at least one elastomer and optionally a non-crosslinked polymer. The device is characterized in that the elastomer composition includes poly(alkylene oxide) groups and that the poly(alkylene oxide) groups are present in the elastomer or polymer as alkoxy-terminated grafts of polysiloxane units, or as blocks, the grafts or blocks being linked to the polysiloxane units by silicon-carbon bonds, or as a mixture of these forms.

Devices for the delivery of drugs having antiprogestinic properties

Block copolymers and preparation thereof

The invention relates to a delivery device for the controlled release of the therapeutically active agent gestodene, over a prolonged period of time, at a release rate of 0,1-300 &mgr;g/day, said device comprising a core comprising at least said therapeutically active agent, and a membrane encasing said core wherein said membrane is made of an elastomer. According to the invention, the elastomer is a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units, and the release rate of said therapeutically active agent of said delivery device is regulated by the amount of said 3,3,3-trifluoropropyl groups.

Drug delivery device, especially for the delivery of gestodene

The invention relates to a delivery device for the controlled release of a therapeutically active agent, especially an androgen, over a prolonged period of time, said device including a core containing the therapeutically active agent, and a membrane encasing the core wherein the membrane is made of an elastomer. According to the invention, the elastomer is a siloxane-based elastomer which includes 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units.

Drug delivery device, especially for the delivery of androgens

The invention relates to a delivery device for the controlled release of a therapeutically active agent, especially a progestin or an estrogen, over a prolonged period of time, said device including a core which contains the therapeutically active agent, and a membrane encasing the core wherein said membrane is made of an elastomer. According to the invention, the elastomer is a siloxane-based elastomer which includes 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units.

Drug delivery device especially for the delivery of progestins and

Chromatographic purification of cyclosporing using a high pressure

Process for the preparation of methylenebisphosphonic acids

Growing community of inventors

Vanhalinna, Finland

Jarkko Ruohonen