The Procter Gamble Company

Brigham Young University

University of Nebraska

Warner Chilcott Company, LLC

Jared Lynn Randall

Paul B Savage

Jane Ellen Godlewski

Andrew S Thompson

Gary Robert Kelm

Ross A Miller

Jeffrey Joseph Ares

Sunil V Kakodkar

Gregory Kent Bosch

Tuticorin Govindachari Rajagopalan

Thomas Elliott Jacks

Li Sun

Peter D Murray

Candice L Slough

Robert D Leunk

Richard Alan Gibbs

Nicholas Nikolaides

Michael David Curtis

Saurabh Shashikant Chitre

Thomas Elliot Jacks

Kunal Arvind Varia

Ross Allen Miller

Andrew Steven Thompson

Disclosed herein are methods of making ceragnenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad-spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti-inflammatory, bone growth promotion, and wound healing promotion.

Methods for the synthesis of ceragenins

Disclosed herein are methods of making ceragenin compounds for treating, preventing, or diagnosing diseases, disorders, or conditions associated with bacterial or viral infections, cancer, inflammation, and osteogenesis. Ceragenin compounds display broad spectrum antibacterial activity utilizing a mode of action similar to antimicrobial peptides, but without the high synthesis costs and susceptibility to proteolytic degradation. Ceragenin compounds reproduce the amphiphilic morphology found in many antimicrobial peptides and display potent and diverse biological activities, including anti-bacterial, anti-cancer, anti -inflammatory, bone growth promotion, and wound healing promotion.

6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

6-[(4,5-Dihydro-1H-imidazol-2-yl)amino]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt

Process for preparing quinolone antibiotic intermediates

The present invention provides processes for making compounds of the structure

Process for making quinolonyl lactam antimicrobials and novel

The present invention provides a process for making a compound having a structure according to Formula (I) ##STR1## wherein A.sup.1, A.sup.2 and A.sup.3 are independently carbon or nitrogen and R.sup.1, R.sup.3, R.sup.4 and R.sup.6 are known quinolone substituents; and wherein one of R.sup.1, R.sup.3 or R.sup.6 may be a lactam-containing moiety;

Process for making antimicrobial compounds

The subject invention relates to methods for preventing or treating damage to the mucosal lining of the gastrointestinal tract of a human or lower animal by administering a safe and effective amount of a compound having the structure: ##STR1## wherein X and Y are each independently selected from O and S; R.sup.1, R.sup.2 and R.sup.3 are each independently selected from hydrogen, hydroxy, halo, unsubstituted or monosubstituted straight or branched C.sub.1 -C.sub.4 alkanyl, and unsubstituted or substituted straight or branched C.sub.1 -C.sub.4 alkanoxy; and each of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is hydrogen or, if one or more of R.sup.1, R.sup.2 and R.sup.3 is other than hydrogen, each of R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is selected from hydrogen, halo, trifluoromethyl, and unsubstituted straight or branched C.sub.1 -C.sub.4 alkanyl.

Use of flavone derivatives for gastroprotection

The subject invention relates to methods for providing mucosal-protection comprising administering to a human or lower animal a safe and effective amount of an extract from plant species of the genera Wedelia, Eclipta and Aspilia.

Plant extracts as mucosal-protective agents

The subject invention involves pharmaceutical compositions comprising a sulfated glyceroglucolipid having the structure: ##STR1## wherein n is an integer of from 1 to about 5, R is hydrogen or C.sub.1 -C.sub.24 acyl or alkyl, R' is hydrogen or C.sub.1 -C.sub.24 acyl or alkyl, and M.sup.+ is a cationic moiety, and methods of treating or preventing gastroduodenal diseases or disorders caused by or associated with H. pylori by administering such compounds.

Sulfated glyceroglucolipids as inhibitors of bacterial adherence

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Smyrna, NY, United States of America

Jared Lynn Randall