Abbott Laboratories Corporation

Abbott Diabetes Care Inc.

Medisense, Inc.

Jared L Watkin

Nigel John Forrow

Gurdial Sanghera

Graham J Hughes

Yi Wang

Gary F Prokop

Eric B Shain

Timothy P Henning

Andrew J Muetterties

Douglas F Young

Thomas G Schapira

David Dean Cunningham

Joshua P Goldfarb

Geoffrey Roger Chambers

Stephen Walters

Stephan Walters

Shridhara Alva Karinka

Michael Robert Zocchi

Chad Harold Mace

Mark E Tess

Benjamin J Feldman

Gurdial Singh Sanghera

Nigel F Carter

Geoffrey R Chambers

Steven Scott

Gurdial S Sanghera

An article suitable for conducting one or more assays with an apparatus, e.g., a meter, for determining the presence or concentration of an analyte in a sample of biological fluid. The article contains a plurality of biosensors arranged in such a manner that each of the biosensors can be utilized before the article must be removed from the apparatus.

Multiple-biosensor article

The present invention is based on the discovery of NADand NADPmediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.

Biosensor electrode mediators for regeneration of cofactors

In vitro analyte sensors and methods of analyte determination are provided. Embodiments include sensors that include a pair of electrodes to monitor filling of the sample chamber with sample.

Analyte sensors and methods of use

Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of: In another aspect of the invention, an apparatus for carrying out the method described previously is provided. The apparatus comprises:

Method and apparatus for obtaining blood for diagnostic tests

The present invention is based on the discovery of NAD and NADP mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.

Biosensor electrode mediators for regeneration of cofactors and process for using

Method and apparatus for obtaining a sample of blood from a patient for subsequent diagnostic tests, e.g., glucose monitoring. In one aspect of the invention, the method comprises the steps of:

An electrode strip for use in an electrochemical sensor for measuring a compound in a sample is provided, including an electrode support, a reference or counter electrode disposed on the support, a working electrode spaced from the reference or counter electrode on the support, a covering layer defining an enclosed space over the reference and working electrodes and having an aperture for receiving a sample into the enclosed space, and a plurality of mesh layers interposed in the enclosed space between the covering layer and the support, the covering layer having a sample application aperture spaced from said electrodes and said reference electrode spaced from said working electrode at a position remote from and on the opposite side of said working electrode from said aperture. The working electrode includes an enzyme capable of catalyzing a reaction involving a substrate for the enzyme or a substrate catalytically reactive with an enzyme and a mediator capable of transferring electrons transferred between the enzyme-catalyzed reaction and the working electrode to create a current representative of the activity of the enzyme and representative of the compound.

Electrochemical sensor

Growing community of inventors

Abingdon, United Kingdom

Jared L Watkin