Ibis Biosciences, Inc.

Isis Pharmaceuticals, Inc.

Integrated Protein Technologies, Snc.

Jared James Drader

Steven A Hofstadler

Jose R Gutierrez

Rex O Bare

Jeffrey Christopher Smith

Paul J Gleason

Robert D Miller

James C Hannis

Richard Holmes Griffey

Mark W Eshoo

David J Ecker

Stanley T Crooke

Rangarajan Sampath

Thomas A Hall

John McNeil

Lawrence B Blyn

Jared H Nathanson

Yun Jiang

Vivek Samant

Amy L Schink

Gordon Bruce Collier

Kevin Oberkramer

Ronald K Bergold

Neill K White

Kristin Sannes Lowery

Andrew J Scherer

Venkatraman Mohan

John Picuri

Stanley T Motley

Thomas N Chiesl

Kristin Sannes-Lowery

Philip D Compton

Karl M Cabrera

Stephen A Hofstadler

Neil White

Kevin S Oberkramer

A molecular filtration device and method of use capable of filtering and purifying molecules of a particular characteristic, wherein the amount of molecule to be filtered may be in the nanogram range and may be dispersed in a relatively large volume of solution. The resultant elution may include a substantially pure solution comprising the desired molecule.

Molecular weight filtration system and apparatus

Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to devices, systems, and kits for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.

Multiple-analyte assay device and system

The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.

Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy

The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process.

Mass spectrometry with selective ion filtration by digital thresholding

Provided herein are apparatuses and methods for fragmenting nucleic acids or disrupting cells. For example, some embodiments provide a disposable microfluidic device designed to position a sample to be in direct contact with a high frequency vibrating element that emits an ultrasonic frequency into the sample such that the vibrational energy transduced into the sample results in fragmenting nucleic acids or disrupting cells.

Microfluidic transducer

The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials. The invention further provides mechanisms for combining and integrating the different components and for housing, moving, and storing system components or the system as a whole. The systems may include any one or more or all of these components. The system finds particular use when employed for analysis of nucleic acid molecule using mass spectrometry, however, the invention is not limited such specific uses.

Systems for bioagent indentification

The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.

Ionization probe assemblies

Provided herein is technology relating to testing biological samples and particularly, but not exclusively, to methods for performing multiple, simultaneous real-time assays on a sample in a single-use disposable format. For example, the technology relates to methods employing an apparatus that finds use, for example, for point-of-care diagnostics, including use at accident sites, emergency rooms, in surgery, in intensive care units, as well as for non-medical applications.

Systems, computer program products, and methods useful for handling or managing microplates are provided.

Microplate handling systems and related computer program products and methods

Sample processing units useful for mixing and purifying materials, such as fluidic materials are provided. A sample processing unit typically includes a container configured to contain a sample comprising magnetically responsive particles, and one or more magnets that are in substantially fixed positions relative to the container. A sample processing unit also generally includes a conveyance mechanism configured to convey the container to and from a position that is within magnetic communication with the magnet, e.g., such that magnetically responsive particles with captured analytes can be retained within the container when other materials are added to and/or removed from the container. Further, a sample processing unit also typically includes a rotational mechanism that is configured to rotate the container, e.g., to effect mixing of sample materials disposed within the container. Related carrier mechanisms, sample processing stations, systems, and methods are also provided.

Sample processing units, systems, and related methods

The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly&#x2014; or multiply-charged ions by selective ion filtering carried out by a digital thresholding process.

The present invention provides devices, apparatuses, and systems for lifting and mounting of clinical- and research-related equipment. In particular, the present invention provides a lift and mount system for mass spectrometers (e.g., for time of flight (TOF) mass spectrometers (MS)).

Lift and mount apparatus

Growing community of inventors

Carlsbad, CA, United States of America

Jared James Drader