Egis Gyogyszergyar Rt.

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Egis Gyogyszergyar Nyrt

János Wellmann

Gyula Simig

József Barkóczy

Gábor Szénási

György Lévay

Péter Kótay Nagy

István Gacsályi

András Egyed

Éva Schmidt

Anikó Miklósné Kovács

Endre Kasztreiner

Gyorgy Cseh

Laszlo Jaszlits

Peter Matyus

Gyorgy Rabloczky

Andras Varro

Katalin Pallagi

Laszlo Sebestyen

Maria Kuhar Nee Kurthy

Csilla Leveleki

Nandor Makk

László Hársing

Hajnalka Kompagne

Aniko Tegdes

Bernadett Martonné Markó

Judit Sarossy Nee Kincsesy

Eszter Diesler

György Levay

Gábor Szenasi

Laszlo Szam

Judit Ráczné Bajnógel

Sarolta Vegvari Nee Gyurki

István Gacsalyi

József Barkoczy

Judit Raczne Bajnogel

Anikó Miklosne Kovacs

Péter Kotay Nagy

The invention refers to novel 2H-pyridazine-3-one derivatives of the formula I, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient. The novel compounds possess neuroleptic effect and can be used, primarily, for the treatment of schizophrenia. In formula I, R stands for a hydrogen atom or a C, alkyl group, X and Y represent, independently, a hydrogen atom, a halogen atom or a group of the formula II, with the proviso that one of X and Y means always a group of the formula II, and then the other one stands for a hydrogen atom or a halogen atom, wherein in formula II n has a value of 1 or 2. 

2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient

The invention relates to substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein Ris hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), Ris hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; Rstands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(Calkyl); Z stands for oxygen; or Rand Z together with the groups placed between them form a piperazine ring; and Rstands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.

Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same

The invention relates to novel pyrimido [5,4-b][1,4]oxazine derivatives of the formula (I), and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## wherein R.sup.1 stands for a C.sub.1-4 alkyl group;

Pyrimido[5,4-B][1,4]oxazine derivatives and pharmaceutical compositions

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Budapest, Hungary

János Wellmann