Eth Zurich

Unversität Zürich

Siemens Aktiengesellschaft

Ecole Polytechnique Federale De Lausanne

Csem Centre Suisse D'electronique Et De Microtechnique Sa

Eth Zurich, Eth Transfer

Exaddon Ag

Ecole Polytechnique Féderale De Lausanne (epfl)

Janos Vörös

Tomaso Zambelli

Michael Gabi

Vincent Milleret

Benjamin R Simona

Martin Ehrbar

Gregoire Courtine

Luca Hirt

Martin Nirschl

Pavel Musienko

Daniel Eberli

Pascal Behr

Marco Schmidt

Jérôme Polesel-Maris

André Meister

Alexandre Lar-Magnac

Lukas Hefermehl

Stephan Ihle

Victoria De Lange

Kaori Sugihara

Marco Habegger

Alexandre Larmagnac

Serge Weydert

Walter Hirt

Edi Liberato Elias

The invention relates to a polymer structure () formed by at least a polymer, wherein said structure () comprises a volume () and a surface (), wherein said polymer comprises a plurality of polymer chains connected by linkings, characterized by a linking density, wherein said linking density increases, particularly monotonously, from the surface () into the volume () of the polymer structure ().

Electrochemically engineered surface of hydrogels, particularly peg hydrogels, for enhanced cellular penetration

A method for manufacturing a three-dimensional object comprises the steps of (a) bringing at least one nozzle in a first position close to a surface of a substrate, (b) delivering through said at least one nozzle at least one reactant to said surface, (c) effecting a solid forming reaction of said at least one delivered reactant such that said at least one delivered reactant undergoes a transition to become a growing solid deposit on said surface under said at least one nozzle, and (d) detecting an interaction of said growing solid deposit with said at least one nozzle.

Method for manufacturing a three-dimensional object and apparatus for conducting said method

The invention relates to a device (), a method, and a kit for analysing liquid samples. The device () comprises a sample layer () having a plurality of liquid permeable test sites () separated by a liquid impermeable barrier region (), and an inlet part () comprising a plurality of inlet channels (), which lead to respective test sites () of the sample layer (), such that a flow connection between said inlet channels () and said respective test sites () is established or can be established, wherein said inlet channels () comprise first openings () and second openings (), wherein a second surface area defined by the positions of said second openings () is smaller than a first surface area defined by the positions of said first openings () The invention further relates to a method for functionalizing a sample layer ().

Device and method for analysing liquid samples

The invention relates to a method, a device and a system for producing particularly a hydrogel () and for controlling an enzymatically catalyzed formation of a covalent bond in a solution, wherein said covalent bond is formed between a first compound () comprising a first moiety () and a second compound () comprising a second moiety (), wherein the first and the second moiety () are a substrate of an enzyme wherein said enzyme catalyzes the formation of a covalent bond between the first and the second moiety (), and wherein a voltage is applied to the solution for spatially controlling said formation, wherein said voltage is adjusted such that it induces electrolysis of said solution.

Method, device and system for spatially controlling the formation of a hydrogel electrochemically

An implantable device for the electrical and/or pharmaceutical stimulation of the central nervous system, especially the spinal cord, is suggested. The device comprises a conformable substrate which is primarily composed of a flexible and stretchable polymer, and a plurality of flexible electrodes and conductive leads embedded in the conformable substrate. Not only the substrate, but also the leads are stretchable. The substrate may consist of PDMS, and the leads may consist of a conductive PDMS, in particular, PDMS with an electrically conductive filler material, and may optionally be metal-coated. The device defines a multi-electrode array which may be employed for neurostimulation in the epidural or subdural space of an animal or human.

PDMS-based stretchable multi-electrode and chemotrode array for epidural and subdural neuronal recording, electrical stimulation and drug delivery

Small and extremely small molecules and ions or atoms may be detected with the novel device with exceptional sensitivity. The detection is implemented in a simple manner by the known acoustic resonator FBAR or by means of other technologies that measure the physical properties of the filled layer. The permeability of substances (e.g. active ingredients) through membranes such as cell membranes, lipid bilayers, and cell walls can be examined by combining a sensor with the reservoir and the membrane.

Biochip sensor

The invention relates to a probe arrangement () for exchanging in a controllable way liquids with micro-sized samples of material like biological cells, especially in connection with an scanning probe microscope, said probe arrangement () comprising a probe holder () with at least one embedded first channel () and a cantilever () with at least one embedded second channel () and being provided to be attached to said probe holder () in a way that at least one aperture () of the first channel () is connected to at least one aperture () of the second channel () in a way that permits the liquid-tight transfer of a liquid between said first and second channels (). A safe and easy use of the probe arrangement is achieved by having the cantilever () permanently attached to said probe holder () to form a prefabricated probe unit ().

Probe arrangement for exchanging in a controllable way liquids with micro-sized samples of material like biological cells

A medical device is disclosed, which comprises a functional unit (C) for permanent or temporary placement in the urogenital tract of a human or animal body. The functional unit has at least one electrically conducting portion. A power source (G) supplies a current to the electrically conducting portion after placement of the functional unit in the urogenital tract. In this manner, the growth of bacteria on the functional unit can be reduced.

Prevention of bacterial adherence and growth in an urological implant

A probe arrangement with a probe for local electrophysiological analysis of cells () such as patch-clamp techniques for use with atomic force microscopy, has a probe with a cantilever arm () connected to a probe holder (). The probe has a probe tip () at a probing end () of the cantilever arm () and a fluid channel () in the cantilever arm () connecting a probe tip aperture () with a fluid reservoir () via a duct (). The fluid channel (), the duct () and the fluid reservoir () are adapted to be filled with a fluid solution () enabling ion transport for electrophysiological analysis. A first electrode () for electrophysiological analysis is placed in the fluid reservoir () and/or in the duct () and/or in the fluid channel ().

Probe arrangement

Growing community of inventors

Zurich, Switzerland

Janos Vörös