Richter Gedeon Vegyeszeti Gyar Rt

Creighton University

Innofinance Altalanos Innovacios Penzintezet

Reanal Finomvegyszergyar

Solvo Biotechnology

Mta Kutatas-es Szervezetelemzo Intezete

Biosignal Kutato-fejlesztokft

Richter Gedeon Veyteszeti Gyar R.t.

Janos Seprodi

Istvan Teplan

Zsolt Vadasz

Imre Mezo

Judit Erchegyi

Aniko Horvath

Balazs Szoke

Borbala Vincze

Istvan Palyi

Judit Horvath

Orsolya Csuka

Istvan Schon

Tamas Szirtes

Sandor Lovas

Gyorgi Keri

Geza Toth

Gabor Makara

Karoly Nikolics

Sandor Vigh

Magdolna Kovacs

Bela Kanyicska

Ferenc Antoni

Adrienn Kalnay

Balas Szoke

Peter Peczely

Tibor Muray

Istvan Gyorvari

Judit Rchegyi

Andras Szell

Richard F Murphy

Gyongyi Bokonyi

Miklos Idei

Olga N Nee Kuprina

Agnes Balogh

Imre Mezom

Gizella Turi

Gyorgy Rappay

Edit Hegedus

Melinda Mora

Maria Magocsi

Andras Selmezci

The present invention provides peptides and pharmacologically active compounds including gonadotropin-releasing hormone (GnRH) analogues according to formulas of the invention, wherein the compounds show an antitumor effect. The invention additionally provides compositions including these peptides and compounds.

GnRH analogues with antitumour effects and pharmaceutical compositions thereof

The invention features novel peptide derivatives called Reversins, and provides for their use in a method of reducing the activity of the multi-drug transporter protein MDR1 in order to overcome multidrug resistance in a mammal. The peptide derivatives are of the formula (I) X,-X,-X,(X,),-X,, wherein n is 0 or 1, and each n is the same or different; X,is BOC, BOC-Asu, Z-Asu, benzyloxycarbonyl, Glu(OBzl)-OBzl, Trp-OMe, Trp-Phe-OMe, Phe-Trp-OMe, Phe-Phe-OtBu, Trp-Trp-OtBu, indoloacetyl, benzoyl, an alkylanine of 1-4 carbons, dibenzylamide, tryptamide, 1-amino-adamantine, aminomethylcyclohexane, indoline, phenylethylamide or dicyclohexylamide; X,is Glu(OBzl), Asp(OBzl), succinyl, O,O-dibenzoyltartaroyl, diphenoyl, muconyl, Thx, Cpa, Asu, Nal, Pen, Phg, Dbt, Lys(BOC), Lys(Z), Cys(Bzl), Thr(Bzl), Glu(OtBu), tert.-Leu, Leu, Nle, Pro, Phe, Tyr(Bzl), or Ser(Bal); X,is Asp, Asu, Lys, Glu, Trp, Thx, Cpa, Nal, Pen, Phg, Dbt, Glu(OtBu), tert.-Leu, Leu, Nle, Pro, Tyr, Phe, or Tyr(Bzl); X,is BOC-Glu(OBzl), Glu(OBzl), Asu, OBzl, Bzl, BOC, BOC-Lys(BOC), Z-Glu(OtBu), Asp(OBzl), Asp(OBz)-OBzl, benzyloxycarbonyl, O-(cyclo-hexyl), fluorenylmethyl ester, Glu(OtBu), Glu(OtBu)-OBzl, 1-amino-adamantine, aminomethylcyclohexane, indoline, phenylethylarnide, or dicyclohexylamide; and X,is OMe, OBzl, OtBu, Phe-OMe, -O-(cyclohexyl), Trp-OMe, (chlorophenyl)-isobutylamide, fluorenylmethyl ester, ONp, 1-aminoadamantane, aminomethylcyclohexane, indoline, phenylethylamide, or dicyclohexylamide.

Compounds for reversing drug resistance

The invention relates to tumor-inhibiting heptapeptide and octapeptide amide derivatives and to a method of treating mammals, including men, suffering from tumors or from the excessive secretion of insulin, glucagon or growth hormone using these compounds.

Tumor growth-inhibiting somatostatin analogues, pharmaceutical

The invention relates to new peptides of the formula ##STR1## wherein R.sup.2 represents Ala or D-Ala,

Analogs of growth hormone releasing factor (GRF) and a method for the

The present invention relates to novel gonadoliberine analogues of formula I

Gonadoliberine analogues of high activity

The invention relates to a process for increasing the sexual activity of birds and useful domestic mammals and for preparing spermatozoa suitable to their propagation. The process of the invention comprises treating sexually mature male birds or useful domestic mammals at least twice and at most four times with 0.1 to 5 .mu.g/kg of body weight of a compound of the general formula (I),

Process for increasing the sexual activity of birds and useful domestic

The invention relates to novel gonadoliberine derivatives of the general formula (I) ##STR1## wherein X represents an --O--R group wherein R is a benzyl group or a C.sub.1-4 alkyl group, an ##STR2## group wherein R1 and R2 independently stand for hydrogen, a C.sub.1-5 alkyl, aryl, aryl-C.sub.1-2 -alkyl, morpholino, 1-indolinyl or 1-pyrrolidinyl group,

Gonadoliberin derivatives containing a .beta.-aspartyl group, a process

Gonadoliberin derivatives process for the preparation and pharmaceutical

Growing community of inventors

Budapest, Hungary

Janos Seprodi