Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Egyt Gyogyszervegyeszeti Gyar

Mta Kozponti Kemial Kutato Intezete

Biocal Cyogyszergvar

Mta Zozponti Kemiai Kutato Intezet

Mta Kozponti Kemiai Kutato Intezete and Biogal Gyogyszergyar

Janos Sagi

Attila Szemzo

Laszlo Tvos

Anna Szabolcs Nee Borbas

Sandor Jancso

Gyorgy Bacsa

Istvan Csernus

Katalin Marossy

Helga Tudos Nee Feuer

Zsuzsa Veres

Istvan Szinai

Eva Medgyesi Nee Lukacs

Miklos Vajda

Katalin Marmarosi Nee Kellner

Istvan Horvath

Janos Nagy

Laszlo Otvos

Erzsebet Radvanyi Nee Hegedus

Iren Fellegvari

Katalin Ebinger

Pal Ivan

Ildiko Fritzsche Nee Lukacs

Ottone Szabolcs

Gyula Sagi

Eva Ruff

Ferencne Tudos

Marya Hornyak Nee Hamori

Jozsef Schwartz

Edit Cseh

Klara Bujtas Nee Tolgyes

Zoltan Szigeti

Maria Peredy Nee Kajtar

Csilla Rethati

Istvan Koczka

A 12 to 30 nucleotide-unit long oligonucleotide that comprises at least one 5-substituted uracil or cytosine, where the 5-substituent is a C.sub.3-6 n-alkyl, a vinyl, a butenyl, an ethynyl, or a C.sub.4-12 n-1-alkynyl, with the proviso that the uracil moiety may not be substituted with an n-alkyl or a C.sub.8-12 n-1-alkynyl.

Oligodeoxynucleotides containing 5-alkyl, 5-(1-alkenyl)- and

A method of treating herpes eye infections with an ophthalmic composition comprising 5-propyl-2'-deoxyuridine.

Method of treating herpes eye infections with 5-propyl-2'-deoxyuridine

The invention relates to an externally applicable, antiviral pharmaceutical composition accumulating in the skin for treating herpes infections, which composition comprises 0.2-5% by mass of 5-isopropyl-2'-.beta.-deoxyuridine admixed with carriers, diluents and/or other additives conventionally used in the production of pharmaceutical compositions for external use.

Topical process for treating herpes infections using 5-isopropyl-2'-.beta.-

The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, ##STR1## wherein R.sup.1 stands for a hydrogen atom, C.sub.1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C.sub.1-4 alkyl group or a halogen atom, and a process for preparing them by brominating 2',3',5'-tri-O-acyl-5-ethyl-uridine of general formula IV, ##STR2## wherein R is identical with R.sup.1, except where R.sup.1 stands for a hydrogen atom, dehydrohalogenating the resulting dibromo compound of general formula V ##STR3## and optionally deacylating it. The resulting compounds of general formula VI are exhibiting significant potency against Herpes simplex virus species and are of remarkably low acute toxicity.

Process for the preparation of 5-(2-bromovinyl)-uridine

New herbicidal compounds of the formula (I) ##STR1## wherein A is oxygen or sulfur;

Herbicide composition and process for the preparation of the active

Growing community of inventors

Budapest, Hungary

Janos Sagi