Egyt Gyogyszervegyeszeti Gyar

Gyogyszerkutato Intezet

Teva Hungary Pharmaceutical Marketing Private Limited Company

Teva Hungary Ltd.

Ivax Drug Research Ltd.

János Kuszmann

Gábor Medgyes

Nicholas S Bodor

István Kurucz

Pal Berzsenyi

Endre Csanyi

Pal Sohar

Emilia Kiraly Nee Vida

Ferenc Andrasy

The invention relates to polysulfated glycosides of formula (I), the pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions containing these compounds as active ingredients. Furthermore the invention provides a method of preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders of the airways of mammals&#x2014;including asthma and asthma-related pathologies.

Polysulfated glycosides and salts thereof

The invention relates to new stereoisomeric 1,4;3,6-dianhydro-2,5-diazido-2,5-dideoxy-hexitols of the Formula I. These compounds can be prepared by

1,4;3,6-Dianhydro-2,5-diazido-2,5-dideoxy-hexitols

The invention relates to 1,6-dimesyl-3,4-dimethyl-D-mannitol of the formula (I), ##STR1## wherein Ms is mesyl and Me is methyl. This compound is a potent cytostatic agent which can be used to advantage in the therapy of various tumorous diseases. 1,6-Dimesyl-3,4-dimethyl-D-mannitol is prepared according to the invention by subjecting 3,4-dimethyl-D-mannitol to partial mesylation followed by acylation, and splitting off the acyl groups of the resulting compound of the general formula (III), ##STR2## wherein Ms and Me are as defined above and R is a saturated lower aliphatic group, with an acidic alcohol.

1,6-Dimesyl-3,4-dimethyl-D-mannitol and a process for the preparation

Growing community of inventors

Budapest, Hungary

János Kuszmann