Egis Gyogyszergyar

Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag

Egis Gyogyszergyar Nyilvanosan Muekoedoe

Janos Imre

Kalman Nagy

Gyula Simig

Pal Benko

Attila Mandi

Jozsef Barkoczy

Frigyes Gorgenyi

Balazs Volk

Daniel Bozsing

Ferenc Lorant Bartha

Peter Tompe

Ivan Beck

Istvan Simonyi

Adrienn Keszthelyi

Laszlo Levai

Eva Furdyga

Eva J Tajthy Nee Juhasz

Gyorgyi Kovanyi Nee Lax

Gyorgy Mikite

Gyorgyi Zalavari Nee Dosa

Eva Poczik

Ilona Dinnyes Nee Nagy

Erzsebet Kiss Nee Bertok

Gyorgy Krasznai

Eva Sipos

Gyorgy Ruzsics

Gyorgyi Kovanyine Lax

Gyoergy Ruzsics

Peter Slegel

Gyoergyi Kovanyine Lax

Gyoergy Clementis

Valeria Hoffmanne Fekete

Gyoergy Krasznai

Gyoergy Morovjan

Gabor Bagyinszki

Gyorgy Morovjan

The present invention is related to intermediates useful in the preparation of pharmaceutically acceptable salts of (+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-(3R,5S)-dihydroxy-hept-6-enoic acid and polymorphs of said intermediates, methods for preparation thereof and use thereof.

Method for the preparation of high-purity pharmaceutical intermediates

The present invention relates to crystalline Form I rosuvastatin zinc (2:1) salt, method of preparation thereof and use thereof as pharmaceutically active ingredient for the treatment of diseases related to lipid metabolism including hyperlipoproteinemia, hypercholesteremia, dyslipidemia and atherosclerosis.

Crystalline form I rosuvastatin zinc salt

The invention relates to a process for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitro-phenyl)-pyridine-3,5-dicarbo xylate of the Formula I ##STR1## which comprises a) reacting a compound of the general Formula II ##STR2## (wherein n is 1 or 3; if n is 1, then R stands for a group of the Formula (a) ##STR3## and if n is 3, then R represents hydrogen) with methyl acetoacetate of the Formula III

1,4,Dihydro-pyridine intermediates

The invention is directed to processes for the preparation of dimethyl-1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5-dicarbox ylate by reacting 1-methoxy-1-(2'-nitrophenyl)-N-(2'-nitrophenyl)methylene methanamie or 1-(2'-nitrophenyl)-N,N'-bis-(2'-nitrophenyl) methylene methanediamine with methyl acetoacetate in the presence of an amine compound or by reacting the monomeric or trimeric from of 2-nitrobenzaldimine with methyl acetoacetate.

Process for the preparation of 1,4-dihydro-pyridine derivatives

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Budapest, Hungary

Janos Imre