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University of Debrecen

Lajos Kossuth University

Janos Borbely

Magdolna Bodnar

Ildiko Schriffertne Denyicska

John F Hartmann

Andrea Keczanne Uveges

Tunde Rente

Istvan Hajdu

Mihaly Szatmatri

Reka Melinda Molnar

Jozsef Kollar

Gyorgy Vamosi

Methods are disclosed for preparing novel biodegradable nanoparticles based on complexation of poly-gamma-glutamic acid (&#x3b3;-PGA) or its cross-linked derivatives with bivalent lead ions. The final products are stable in aqueous media at low pH, neutral and mild alkaline conditions. The size of the complexes depends on the pH, concentrations and the ratios of &#x3b3;-PGA and lead ions The &#x3b3;-PGA nanoparticles made from biodegradable biopolymers with high flocculating and heavy metal binding activity of the present invention may be used for various water treatment applications in aqueous media.

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Macromolecular contrast agents for magnetic resonance imaging are described. Biomolecules and their modified derivatives form stable complexes with paramagnetic ions thus increasing the molecular relaxivity of carriers. The synthesis of biomolecular based nanodevices for targeted delivery of MRI contrast agents are described. Nanoparticles (NP) have been constructed by self-assembling of chitosan (CHIT) as polycation and poly-gamma glutamic acids (PGA) as polyanion. NP's are capable of Gd-ion uptake forming a particle with suitable molecular relaxivity. Folic acid (FA) is linked to the NP's to produce NP-FA bioconjugates that can be used for targeted in vitro delivery to a human cancer cell line.

Cancer cell diagnosis by targeting delivery of nanodevices

Methods are disclosed for preparing novel biodegradable cross-linked nanoparticles based on covalently cross-linking modifications of hyaluronic acid. The final products of the present invention are stable in aqueous media, and may be used as detergents and as additives for pharmaceutical compositions for drug delivery, DNA carrier system and other applications. The nanoparticles made from the biopolymers of the present invention may also be used in controlled release applications, super-absorbent materials as well as biomaterials like enzyme immobilization.

Hyaluronic acid-based cross-linked nanoparticles

The present invention relates to core/shell vinyl polymers wherein an at least partially crosslinked core is formed from a monovinyl monomer and/or a di/tri/ or higher multivinyl monomer wherein the degree of crosslinking in the core ranges from slight to high depending on the ratio of monovinyl and/or di/tri/ or higher multivinyl monomers, and wherein the outer shell is formed from a monovinyl and/or a di/tri/ or higher multi-vinyl monomer that optionally may be crosslinked, and wherein the outer shell has on its surface linear or branched C.sub.3-C.sub.30 alkyl chains formed from substituted vinyl monomers.

Polymeric product for film formation

Methods are disclosed for preparing crosslinked core and core-shell nanoparticle polymers from chitosan. The final products of the present invention may be used as detergents and as additives for pharmaceutical composition and for drug delivery, and DNA carrier system. The nanoparticles made from biopolymers of the present invention may also be used in controlled release, superabsorbent materials and biomaterials like enzyme immobilization.

Nanoparticles from chitosan

Methods are disclosed for preparing partial and complete esters of poly-&ggr;-glutamic acid, and of the cross-linking of such esters by light of predetermined wavelength. The final products of the present invention are useful in local drug delivery in depot form, for guided tissue regeneration, and for inhibition of post-surgical adhesion.

Growing community of inventors

Debrecen, Hungary

Janos Borbely