Biogal Gyogyszergyar

Biogal Gyogyszergyar Rt.

Biogal Gyogyszergrar

Biogal Gyogyszerarugyar Rt

Janos Balint

Gyorgy Toth

Vilmos Keri

Sandor Jancso

Laszlo Cseke

Miklos Szarvas

Lajos Kun

Eva Mudra Nee Kantor

Klara Elek Nee Herczik

Zsuzsanna Moricz Nee Garai

Ferenc Fabian

Csaba Szabo

Rezso Bognar

Karoly Lapis

Istvan Csernus

Antal Kovacs

Istvan Kovacs

Bela Szende

Istvan Melczer

Geza Horvath

Ildiko Mihok Nee Borbely

Eva Horvath Nee Feher

Zsuzsanna Emri

Gyorgy Deak

Judit Dencs

Zoltan Konyari

Janos Kelemen

Csaba Hajdufi

Anita Karczub

Gyula Marton

Gyorgy Sulyok

Ferenc Vinczi

Ildiko Borbely

SzilaJudit

Ferenc D Toth

Nelli Sas

Jolan Kiss

Zoltan Gyorgydeak

Tibor Szanya

Attila Jakab

Terezia Mile

Janos Erdelyi

Edit Nagy

Mariann Fekete Nee Huszka

Imre Z Nagy

Judit Krusper Nee Ham

Ilona Himesi

Ferenc Pusztai

Laszlo Hanak

Andras Jenei

Gyongyi Strbka

Laszlo Eszenyi

Berta Mako

Ferenc Radnai

Sandor Horkay

Erno Karacxony

The invention relates to a compound of formula (I) ##STR1## wherein X is a pharmacologically acceptable anion,

Flavilium compounds and method of using

The subject matter of the invention is a process for the preparation of carboxylic acids and derivatives of them of the general formula ##STR1## wherein R means hydrogen, or a C.sub.1-4 alkyl or a (C.sub.1-5 alkoxy)carbonyl group,

Process for the preparation of carboxylic acids and derivatives of them

A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80.degree. C. to about 115.degree. C., melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48:50:2 mixture of chloroform, dichloromethane, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethylacetate, and ethanol.

Process for the purification of cyclosporin A

A process for the preparation of high-purity deferoxamine salts from filtered fermentation liquors containing deferoxamine B as active ingredient by the adsorption of the active ingredient onto an ion exchange resin and the subsequent dissolution and purification thereof, which comprises carrying out the separation of the deferoxamine salt subsequent to the concentration of the eluate by salting out from an aqueous solution or from a mixture of water and an organic solvent and purifying it by repeated salting out and/or by methods known per se, and optionally

Process for the preparation of high-purity deferoxamine salts

The invention relates to novel thiazolidine-4(S)-carboxylic acid derivatives of the general formula (I) ##STR1## wherein R.sup.1 stands for an optionally substituted furyl, pyrrolyl, thienyl, benzofuryl, benzopyrrolyl, benzothienyl, phenyl, pyridyl, quinolinyl, isoquinolinyl or indanyl group or a C.sub.1-4 alkyl or C.sub.2-4 alkenyl group optionally substituted by a hydroxyl, carboxyl or halogen fenoxy group,

Thiazolidinecarboxylic acid derivatives and treatment of liver diseases

This invention relates to the new 1,3-bis-(dimethylamino)-2-propyl-4-chlorophenoxyacetate of the Formula (I) ##STR1## acid addition salts thereof, a process for the preparation of the same and pharmaceutical compositions comprising the said compounds. The novel compound of the present invention corresponds to the Formula (I). This compound stimulates the function of the brain cells and thereby mental activity. The compound of the Formula (I) can be prepared by esterifying (4-chlorophenoxy)-acetic acid or a functional reactive derivative thereof with 1,3-bis-(dimethylamino)-2-propanol or a halogeno derivative thereof in a manner known per se.

1-3,bis(dimethylamino)-2-propyl-4-chlorophenoxy-acetate, acid addition

The invention relates to a process for the preparation of an oxytetracycline-calcium silicate complex salt from fermentation broth. By the process according to the invention the valuable antibiotic oxytetracycline may be separated from the fermentation broth in an easy manner. The complex obtained according to (a) contains up to 50% of antibiotic and is suitable for the processing in the pharmaceutical industry while the product according to (b) contains 10 to 20% of antibiotic and may be used as fodder additive directly.

Process for the preparation of an oxytetracycline-calcium silicate

The invention relates to a new process for the preparation of easy-flowing (flowable) oxytetracyclin hydrochloride. According to the process of the invention, the crude, dry or filter-wet oxytetracyclin hydrochloride consisting of needle-shaped crystals is boiled with an organic solvent forming an azeotropic mixture with water, optionally a part of the solvent is distilled off in a form of an azeotropic mixture, then the mixture is cooled and the precipitated oxytetracyclin hydrochloride consisting of spherical crystals is separated and dried. Oxytetracyclin hydrochloride exists in two various crystal forms, the one of which is needle-shaped, while the other one consists of orthorhombic sheets. The crystals of this latter form are capable of forming spherical particles by coalescence. The crystal form consisting of spherical particles is much more useful for the pharmaceutical industry. By means of the new process easy-flowing (flowable) oxytetracyclin hydrochloride can be prepared in a favorable yield and with a high purity from the crude hydrochloride product consisting of needle-shaped crystals.

Process for the preparation of easy-flowing (flowable) oxytetracyclin

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Debrecen, Hungary

Janos Balint