Enzo Life Sciences, Inc.

Enzo Biochem, Inc.

Enzo Diagnostics, Inc.

Enzo Life Sciences, Inc. C/o Enzo Biochem, Inc.

Enzo Therapeutics, Inc.

C/o Enzo Biochem, Inc.

Enzo Life Science, Inc. C/o Enzo Biochem Inc.

Jannis G. Stavrianopoulos

Elazar Rabbani

James J. Donegan

Jack Coleman

Marleen Walner

Jannis G Stavrianopoulos

Elazar S Rabbani

James J Donegan

Dakai Liu

Praveen Pande

Dean L Engelhardt

Dollie Kirtikar

Joshua Rabbani

Stanley Kline

Norman E Kelker

Wayne Forrest Patton

Juan Carcamo

Kenneth H Johnston

Barbara E Thalenfeld

Robert G Pergolizzi

Sherry P Goltz

Elazar Babbani

Stan Kline

Elazar Rabban

Paula J Olsiewski

Elazar Rabbam

Norman E Keller

Heuy-Lang Yang

James G Wetmur

Samuel B Abrams

Flazar Rabbani

James G Donegan

Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.

Assays for detecting modified compounds

The present invention concerns compositions and processes that use affinity tags for isolating, and detecting or quantifying analytes, including nucleic acids, proteins and polypeptides. Compositions include nucleic acid compositions and protein compositions with affinity binding pairs, including metal binding peptides and immobilized metals, or peptide affinity groups.

Affinity tag nucleic acid and protein compositions, and processes for using same

Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.

Multisignal labeling reagents and processes and uses therefor

This invention provides for compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.

Processes for quantitative or qualitative detection of single-stranded or double-stranded nucleic acids

This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.

Compositions and processes for analyte detection, quantification and amplification

Composition of matter comprising library of first nucleic acid analyte copies

Process for detecting or quantifying nucleic acids in a library

Arrays comprising chimeric compositions

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Bay Shore, NY, United States of America

Jannis G Stavrianopoulos