American Cyanamid Company

Janis Upeslacis

Seymour Bernstein

Robert E Schaub

Robert G Shepherd

Martin L Sassiver

Philip R Hamann

Vern G DeVries

William J McGahren

George A Ellestad

Lois M Hinman

Keith C Murdock

Thomas L Fields

This disclosure describes a method for constructing targeting agent drug conjugates from the family of methyltrithio antibacterial and antitumor agents.

Process for preparing targeted forms of methyltrithio antitumor agents

This disclosure describes a method for constructing carrier-drug conjugates from the family of methyltrithio antibacterial and antitumor agents.

Targeted forms of methyltrithio antitumor agents

Antitumor amino acid and peptide derivatives of 1,4-bis[(aminoalkyl and hydroxyaminoalkyl)amino]-5,8-dihydroxyanthraquinones.

Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and

This invention is concerned with novel 4-[(trialkylsilyl)alkylamino]phenyl compounds and their use as antiatherosclerotic agents.

Antiatherosclerotic silanes

This disclosure describes novel diaryl-alkanamides. These compounds are useful as pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.

Antiatherosclerotic diphenyl alkanamides

This disclosure describes novel substituted aralkanamidobenzoic acids and analogs thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.

Aralkanamidophenyl compounds

This disclosure describes novel [Bis(phenyl or substituted phenyl)alkyl]amino benzoic acids, esters, and derivatives thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.

Arylalkylaminobenzoic acids

Poly-cation salts of bis(or tris)[4-O-monohexose-oxy]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and products.

Poly-cation salts of bis(or tris)[4-O-monohexose-oxy]-arylene sulfate

Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.

Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate

Poly-cation salts of bis (4-O-polyhexaose-thio)-phenyl urea sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.

Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use

Poly-cation salts of bis(or tris)[4-O-monohexose-thio]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.

Poly-cation salts of bis(or tris)[4-0-monohexose-thio]-arylene sulfate

Poly-cation salts of bis (or tris) [4-O-polyhexose-oxy]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.

Polycation salts of bis (or tris) [4-O-polyhexose-oxy]-arylene sulfate

N,N'-Bis[4-[(2,3,4,6-tetra-O-sulfo-.alpha.(or .beta.)-D-glucopyranosyl)thio(or oxy)]phenyl]alkyl diamides, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process for the preparation of such intermediates and end products.

Poly cation salts of monohexosethio (or oxy) alkyl diamides

N,N'-Bis[4-[2,3,6-tri-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-.alpha.(and .beta.)-D-glucopyranosyl)-.alpha.(and .beta.)-D-glucopyranosyloxy]phenyl]alkyldiamides and alkyldiamines, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.

N,N'-Bis(glucopyranosyl-D-glucopyranosyloxyphenyl)alkaline and methods

N,N'-Bis[4-[2,3,6,-tri-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-.alpha.(and .beta.)-D-glucopyranosyl)-.alpha.(and .beta.)-D-glucopyranosylthio or sulfinyl or sulfonyl]phenyl]alkyldiamides and alkyldiamines, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.

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Pomona, NY, United States of America

Janis Upeslacis