University of Utah Research Foundation

Other

California Institute of Technology

Janis Louie

Robert H Grubbs

John P Morgan

Puneet Kumar

Jason Lee Moore

Diego Benitez

Described herein are methods for synthesizing heterocyclic, 8-membered ring structures. The methods may allow for preparation of highly substituted 8-membered rings. Also disclosed are heterocyclic, 8-membered ring compounds and pharmaceutical compositions comprising the compounds.

Heterocyclic compounds

The invention provides a novel method for synthesizing transition metal carbene complexes useful as olefin metathesis catalysts. The method is a convenient one-pot synthesis in which transition metal carbenes are prepared in high yield from readily available starting materials via a dihydrogen complex containing two different anionic ligands, preferably a phosphine and a heteroatom-stabilized carbene. The invention additionally provides a method for synthesizing precursors to carbene ligands useful, inter alia, in the aforementioned one-pot synthesis. The precursors are in the form of trichloromethyl adducts of the formula L -CCl , where L is a heteroatom-stabilized carbene ligand, and are prepared by contacting an unsaturated, ionized analog of L-CCl with a non-nucleophilic base in the presence of chloroform.

One-pot synthesis of group 8 transition metal carbene complexes useful as olefin metathesis catalysts

Highly active metathesis catalysts generated in situ from inexpensive and air stable precursors

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Salt Lake City, UT, United States of America

Janis Louie