University of California

Janice Richman-Eisenstat

Keith E Mostov

Steven J Chapin

The invention provides compositions and methods for specific binding to a region of the polymeric immunoglobulin receptor (pIgR) of a cell with the provisos that the ligand does not substantially bind to the most abundant form of the secretory component (SC) of pIgR present in an organ of interest of an animal of interest under physiological conditions, and does not bind to the pIgR stalk. In some embodiments, the ligand decreases cleavage of SC from the stalk by at least one-third. The ligands and methods of the invention can be used with both birds and mammals. In more preferred embodiments, the animal is a mammal. In the most preferred embodiment, the animal is a human. The ligand may be targeted into the cell or may undergo retrograde transcytosis and release at the basolateral side of the cell, and may comprise a biologically active composition.

Methods of targeting agents to cells expressing the polymeric immunoglobulin receptor

Ligands directed to the non-secretory component, non-stalk region of plgR and methods of use thereof

Antibody ligands are provided for specific binding to the stalk of a polymeric immunoglobulin receptor (plgr) of a cell with the proviso that the ligand does not substantially bind to secretory component of plgR under physiological conditions. The ligand may be targeted to, into, or across the cell and may comprise a biologically active composition.

Antibodies to PIGR stalk

Compositions and methods for specific binding to the stalk of a polymeric immunoglobulin receptor (pIgR) of a cell with the proviso that the ligand does not substantially bind to secretory component of pIgR under physiological conditions. The ligand may be targeted to, into, or across the cell and may comprise a biologically active composition.

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Winnepeg, Canada

Janice Richman-Eisenstat