Sanofi Pasteur Vaxdesign Corporation

Virginia Commonwealth University

Vaxdesign Corporation

Janice Moser

William L Warren

Donald Drake

Eric Mishkin

Inderpal Singh

Haifeng Song

John G Tew

Luis Mosquera

Vaughan Wittman

Tirumalai Kamala

Evan Gomes

Donald Drake Iii

Donald Iii Drake

Eric Mihkin

In vitro biomimetic models of the neonatal immune system are provided along with methods of using the models in pre-clinical assessment of infant immune cell-mediated and humoral responses to immunogenic stimulation, such as vaccination. The models include one comprising cord blood-derived T follicular helper cells and B cells, and one comprising cord blood-derived dendritic cells and CD4+ T cells. The models can be used, for example, to assess candidate vaccines via analysis of cellular responses to antigen and vaccine exposure.

In vitro neonatal biomimetic (nMIMIC) model and methods of using same

The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics, drugs, biologics and other chemicals.

Methods for testing an immune response using cultures of T cells, B cells, dendritic cells and follicular dendritic cells

Methods for testing an immune response using cultures of T cells, B cells and dendritic cells

Method for determining the immunogenicity of an antigen

Co-culture lymphoid tissue equivalent (LTE) for an artificial immune system (AIS)

Growing community of inventors

Orlando, FL, United States of America

Janice Moser