Memorial Sloan Kettering Cancer Center

Sloan-kettering Institute for Cancer Research

New York University

Sloan-kettering Institute

Janice L Gabrilove

Raymond P Warrell, Jr

Pier Paolo Pandolfi

Karl Welte

Erich Platzer

Malcolm A Moore

Roland Mertelsmann

Malcolm A S Moore

Elaine Lynette Wilson

Roland Mertelsman

Roland Mertelsm

The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.

Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol

Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparant homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5&#xd7;10U/mg protein.

Human pluripotent hematopoietic colony stimulating factor, method of production and use

Highly purified Pluripotent hematopoietic colon-stimulating factor (pluripotent CSF), a glycoprotein (MW ) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparent homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM) early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is U/mg protein.

Human pluripotent hematopoietic colony stimulating factor, method of use

Highly purified Pluripotent hematopoietic colony-stimulating factor (pluripotent CSF), a glycoprotein (MW 19,600) constitutively produced by human tumor cells has been highly purified from low serum-containing conditioned medium to apparant homogeneity. Pluripotent CSF supports the growth of human mixed colonies (CFU-GEMM), granulocyte-macrophage colonies (CFU-GM), early erythroid colonies (BFU-E) and induces differentiation of human leukemic cells. The specific activity of the purified pluripotent CSF in the CFU-GM assay is 1.5.times.10.sup.8 U/mg protein.

Human pluripotent hematopoietic colony stimulating factor and cell line

Fibroblast growth factors are used in vivo, in situ and in vitro to stimulate stem cells, hemopoiesis, the immune system, transplant donor cells, culture and/or engraftment, wherein the use of fibroblast growth factors is disclosed for the stimulation of stem cells or hemopoietic cells, supporting cells and their progeny, in vitro, in situ and in vivo, as well as corresponding engrafting sites in vivo.

Stimulation, production, culturing and transplantation of stem cells by

Method of producing human pluripotent hematopoietic colony stimulating

Pharmacological preparations comprising human pluripotent hematopoietic

Method of administering human pluripotent hematopoietic colony

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New York, NY, United States of America

Janice L Gabrilove