Other

University of Minnesota

The United States of America As Represented by the Department of Health

The United States of America As Represented by the Secretary of Health

Janice B Allen

Sharon M Wahl

Leo T Furcht

James B McCarthy

Nancy L McCartney-Francis

Jeffrey E Everett

Kevin L Billups

Methods for treating ischemia using polypeptides with fibronectin related activity are provided. The methods involve administering an effective amount of one or more polypeptides which include an amino acid sequence corresponding substantially to isolated an amino acid sequence from the 33 kD carboxy terminal heparin-binding region located on the A chain of fibronectin or an RGD-containing amino acid sequence within the 11.5 kD RGDS-mediated cell adhesion region located on all isoforms of fibronectin.

Method for treating ischemia using polypeptides with fibronectin activity

A method for treating acute or chronic inflammatory or autoimmune disorders using polypeptides with fibronectin or related activity is provided. The method involves (administering an amount of) one or more polypeptides corresponding to isolated amino acid residue sequences of the 33 kD carboxy terminal heparin-binding region located on the A chain of fibronectin to effectively suppress inflammation and impairment of tissue function in a patient.

Method for treating acute and chronic inflammatory disorders using

The present invention provides a method for treating chronic inflammatory conditions, including autoimmune diseases by administering an effective amount of an agent, such as a nitric oxide synthase inhibitor, a nitric oxide scavenger, or an inhibitor of tetrahydrobiopterin synthesis, to decrease the amount of nitric oxide present at the site of inflammation.

Method of treating chronic inflammatory diseases

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Wheaton, MD, United States of America

Janice B Allen