University of Miami

The United States of America, As Represented by the Secretary, Department of Health and Human Services

University of Massachusetts

Janice A Egeland

Edward I Ginns

Steven Marc Paul

Marzena Galdzicka

Methods for treating and diagnosing psychiatric affective disorders, e.g., an affective disorder associated with aberrant Sonic Hedgehog (Shh) signaling, by administering to the subject a therapeutically effective amount of an antagonist to Smoothened (Smo), an antagonist to Patched-1 (Ptch-1) and/or an antagonist to Shh.

Aberrant sonic hedgehog signaling in neuropsychiatric disorders

Chromosomal regions comprising loci associated with susceptibility and resistance to bipolar affective disorder have been identified. Methods and compositions are provided for determining the contribution of these chromosomal regions to bipolar affective disorder in an affected family, for determining in an affected family a genotype associated with increased or decreased susceptibility or resistance to bipolar illness, and for assessing an increased or decreased risk of developing bipolar illness for a tested individual from an affected family.

Growing community of inventors

Hershey, PA, United States of America

Janice A Egeland