Millennium Pharmaceuticals Limited

Millenium Pharmaceuticals, Inc.

Other

Janice A Culpepper

Louis Anthony Tartaglia

Robert I Tepper

David W White

The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.

Methods for detection of the Ob receptor and the diagnosis of body weight disorders, including obesity and cachexia

Methods of using the OB receptor antibodies to treat bodyweight disorders

Ob receptor and methods for the diagnosis and treatment of body weight disorders, including obesity and cachexia

The presention invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.

Nucleic acid molecules encoding the cytoplasmic domain of human Ob receptor

Ob receptor

Chimeric proteins comprising the extracellular domain of murine Ob receptor

Ob receptor and methods for the diagnosis and treatment of body weight disorders

Methods of identifying compounds that modulate body weight using the OB receptor

Antibodies to the Ob receptor

Methods of using the Ob receptor to identify therapeutic compounds

Methods of identifying compounds that modulate body weight using the OB

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Brookline, MA, United States of America

Janice A Culpepper