Korea Advanced Institute of Science and Technology

Institute for Basic Science

Seoul National University

Jang Ryul Park

Wangyuhl Oh

Gou Young Koh

Jaeryung Kim

Mi Jeong Kim

Jeomil Bae

Pilhan Kim

Su Jin Seo

Jin-Sung Park

Kyuseok Kim

The present invention relates to mouse antibodies that bind to angiopoietin-2 (Ang2), humanized anti-Ang2 antibodies derived therefrom, and the use thereof. The anti-Ang2 antibodies have a dual function of activating the Tie2 receptor together with neutralizing Ang2. The anti-Ang2 antibodies show the property of normalizing abnormal and pathological blood vessels, and thus exhibits therapeutic efficacy against various diseases and disorders associated with abnormal blood vessels. The present invention further provides an angiogenesis inhibitor and a composition for treatment of diseases associated with abnormal Ang2 expression and Tie2 dysregulation, which comprise the antibody as an active ingredient, and a composition for diagnosing diseases associated with Ang2 inhibition and Tie2 activation, which comprises the antibody.

Anti-angiopoietin-2 antibodies that induce Tie2 activation

The present disclosure relates to an apparatus for angiographic optical coherence tomography in the retina or the choroid, and a method for diagnosing diseases by using the same and, more specifically, to: an apparatus for angiographic optical coherence tomography in the retina and the choroid, capable of diagnosing, at an early stage, shock states or diseases such as those of sepsis by quickly and objectively recognizing the low perfusion of tissue; and a diagnostic method using the same.

Apparatus for angiographic optical coherence tomography in retina or choroid, and method for diagnosing diseases by using same

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Daejeon, South Korea

Jang Ryul Park