Novartis Ag

Corium International, Inc.

Janet Wendorf

Derek T O'Hagan

Parminder Singh

Manmohan Singh

Guohua Chen

Joseph Creagan Trautman

Steven Richard Klemm

Robert Wade Worsham

Danir F Bayramov

Danny Lee Bowers

Esi Ghartey-Tagoe

Steve Williams

Jina Kazzaz

Padma Malyala

Andy Klemm

Andrew Richard Klemm

A microprojection array is provided, comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a vaccine and a polymeric material. The array may have multiple layers. The vaccine may be placed in only one layer. In another embodiment of the invention, a method of preventing a disease is provided, comprising insertion into the skin of a patient an array of microprojections comprising a layer which comprises a vaccine for that disease and a polymer.

Method of vaccine delivery via microneedle arrays

Disclosed herein are sterile-filtered lyophilized nanoparticle compositions which contain at least one biodegradable polymer, at least one surfactant, at least one cryoprotective agent and at least one antigen. Also disclosed are methods of making and using such compositions and kits supplying such compositions.

Nanoparticles for use in immunogenic compositions

Vaccine delivery via microneedle arrays

Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof. Also described are methods of making such compositions and methods of administering such compositions. Methods of modulating the release rate of immunological species from microparticles are also described. These methods comprise varying the ratio of the cationic polysaccharide relative to the biodegradable polymer within the microparticles.

Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions

Growing community of inventors

Redwood City, CA, United States of America

Janet Wendorf