Health Research, Inc.

The State University of New York

Janet Morgan

Ravindra Kumar Pandey

William R Potter

Allan R Oseroff

Chao Liu

Indrajit Roy

Haridas Pudavar

Mahabeer Dobhal

Tymish Y Ohulchansky

Paras N Prasad

Tetrapyrrolic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl6HO to oxidize the D ring and separating the resulting organic layer and drying.

B ring reduced-D ring oxidized tetrapyrrolic photosensitizers for photodynamic therapy and tumor imaging

Growing community of inventors

Buffalo, NY, United States of America

Janet Morgan