The University Court of the University of Aberdeen

Apatech Limited

Sirakoss Limited

Janet Mabel Scott Skakle

Iain Ronald Gibson

Thomas Buckland

Nigel G Smith

Jordan Christopher Conway

Basil Annaz

Nigel Smith

Lain Ronald Gibson

A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprises a compound having the general chemical formula: CaGd(PO)(SiO)x(OH)where 0&#x3c;x&#x3c;1.3 and 0&#x3c;y&#x3c;1.3.

Biomedical materials

A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprise a compound having the general chemical formula: CaGd(PO)(SiO)x(OH)where 0&#x3c;x&#x3c;1.3 and 0&#x3c;y&#x3c;1:3.

The bone graft system comprises a solid inorganic component, which is bone graft material, and a hydrogel. The hydrogel contains &#x3e;2 ppm of silicon ions, calculated as parts by weight of Si per million of the aqueous component of the hydrogel. Preferably, the solid inorganic component comprises hydroxyapatite or a silicon-containing hydroxyapatite, and may be a silicon-containing hydroxyapatite having a Ca/P ratio in the range 2.05 to 2.55 and a Ca/(P+Si) molar ratio less than 1.66. Bone healing is promoted by delivery of silicon ion release from the hydrogel and by the solid inorganic component stimulating cell behavior.

Bone graft system

The invention relates to porous granular calcium phosphate osteoinductive materials, particularly materials useful in body tissue repair, principally bone repair and bone replacement, and also to the use of such materials and to a method of making such materials. Exemplary materials comprise discrete porous granules each containing crystals of at least one calcium phosphate, wherein (i) at least 90% of said crystals of the granules have a crystal size in the range 10-100 nm, (ii) at least 90% of the pores in the granules have a pore size in the range 10-500 nm, (iii) the average pore size of the pores having pore size in the range 10-500 nm in the granules is in the range 30-90 nm, (iv) the total volume porosity of the granules is at least 50%, and (v) the surface area of the granules is in the range 10-70 m/g.

Calcium phosphate material

A process for the synthesis of a bioceramic composition comprising calcium phosphosilicate (CPS, Ca(PO)(SiO)), the process comprising: providing calcium or a calcium-containing compound, a phosphorus-containing compound and a silicon-containing compound; and forming a precipitate by reacting the compounds in an aqueous phase at an alkali pH.

Synthesis of bioceramic compositions

An inorganic silicate-substituted calcium phosphate hydroxyapatite, useful as a biomaterial, has a Ca/P molar ratio in the range 2.05 to 2.55 and a Ca/(P+Si) molar ratio less than 1.66. The hydroxyapatite can be substantially free of carbonate ions. The material has relatively high solubility and is able to release silicon into solution.

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Aberdeen, United Kingdom

Janet Mabel Scott Skakle