Mallinckrodt Hospital Products IP Limited

Johnson & Johnson Research Pty Limited

Therakos Development Limited

Mallinckrodt, Inc.

Therakos, Inc.

Mallinckrodt Pharma IP Trading D.a.c.

Mallinckrodt Critical Care Finance Inc.

Mallinckrodt Hospital Products IP Unlimited

Janet Lesley Macpherson

Geoffrey Phillip Symonds

Susan Pond

Kevin Henrichsen

Philip Wong

David Peritt

Wayne Lyle Gerlach

Lun-Quan Sun

Rafael G Amado

Greg Fanning

Rafael Amado

Geoffery P Symonds

Methods (), devices, and systems of processing blood are described. The method () comprises the steps of: obtaining () blood from a patient coupled to a single blood processing device to form a closed loop between the patient and the blood processing device; collecting () bulk mononuclear blood cells from the blood by leukapheresis implemented using the blood processing device in the closed loop; and enriching () concurrently target cells separated from non-target cells in the bulk mononuclear blood cells using the blood processing device in the closed loop.

Processing blood

Described are compositions and methods relating to gene therapy, particularly as applied to hematopoietic progenitor (HP) cells, to transduced cells and methods of obtaining them, and to methods of using them to provide prolonged engraftment of modified hematopoietic cells in human subjects. The invention particularly relates to ex vivo gene therapy of HP cells for treatment or prevention of HIV infection.

Process for the preparation of a composition of genetically modified hematopoietic progenitor cells

Growing community of inventors

Leichhardt, Australia

Janet Lesley Macpherson