Akzo Nobel N.v.

Akzo N.v.

Intracel Holdings LLC

Janet H Ransom

Nicholas Pomato

Martin V Haspel

Michael G Hanna, Jr

Richard P McCabe

Ebo S Bos

This invention providesantitoxin compositions and methods of production, and methods of treating animals and humans prophylactically and also those suspected of having contacted botulism toxin. Theantitoxin is prepared by inoculating an animal with a monovalenttoxoid and toxin. The animal's plasma is collected and purified at a high pH by affinity chromatography. The resulting monovalent immunoglobulins are de-speciated by digestion with pepsin. Monovalent antitoxins for all sevenserotypes are then combined to produce a high titered heptavalentantitoxin composition.

Botulinum antitoxin compositions and methods

CTAA 81AV78, the antigen recognized by human monoclonal antibody 81AV78

The present invention comprises the epitope recognized by the human monoclonal antibody 28A32, the human tumor antigen containing this epitope, which we have identified, isolated and characterized, and human MCA 28A32. The invention also relates to the use of antibodies to the antigen containing this epitope for diagnosis and monitoring of treatment of cancer and to the use of this antigen in the preparation of vaccines to elicit an immune response similar to that obtained against tumor cells containing this epitope.

CTAA 28A32, the antigen recognized by MCA 28A32

Leukoregulin is identified, a biologically active lymphokine of molecular weight of about 120,000 to 140,000, with subunits of about 30,000 to 35,000, having the isoelectric focusing pH's of between 4.8 and 5.5 or between 7.5 and 8.3, which has the ability to regulate tumor cell physiology and growth without affecting the growth of normal cells. Methods for stimulating its production by monouclear cells, methods for its isolation and purification, and methods for its therapeutic uses are also disclosed.

Leukoregulin, an antitumor lymphokine, and its therapeutic uses

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North Potomac, MD, United States of America

Janet H Ransom