John Wyeth Brother, Limited

American Home Products Corporation

Janet C White

Terence J Ward

John Leheup Archibald

Gerald Bradley

Compounds of formula ##STR1## wherein R.sup.1 is hydrogen or one or more specified substituents,

Certain benzo-quinolizine compounds and derivatives thereof

Certain 1,8-ethano or propano-1,4-dihydro-4-oxo-quinoline-3-carboxamides

Aryl ureas and carbamic acid derivatives of formula

Heterocyclic compounds useful as 5-HT.sub.3 antagonists

Pharmacologically active amides and esters containing an

Aroyl ureas and carbamic acid derivatives of formula

The invention concerns compounds of formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halogen, lower alkoxy or hydroxy; R.sub.2 represents hydrogen or lower alkyl; A represents an alkylene, oxoalkylene or hydoxyalkylene chain each having 2 to 6 carbon atoms, R.sub.3 and R.sub.4 may be in the same or different rings and independently represent hydrogen, lower alkyl, lower alkoxy, amino or halogen and one of X and Y represents nitrogen the other represents CR.sub.5 wherein R.sub.5 is one of the values for R.sub.3 or R.sub.5 is the bond to the NHCO group; or a pharmaceutically acceptable salt thereof, which compounds possess antihypertensive activity whilst exhibiting reduced CNS depressant properties. Also disclosed are processes for preparing the compounds and pharmaceutical compositions containing them.

Indole derivatives

The invention concerns compounds of formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halogen, lower alkoxy or hydroxy; R.sub.2 represents hydrogen or lower alkyl; A represents an alkylene, oxoalkylene or hydroxyalkylene chain each having 2 to 6 carbon atoms, R.sub.3 and R.sub.4 may be in the same or different rings and independently represent hydrogen, lower alkyl, lower alkoxy, amino or halogen and one of X and Y represents nitrogen the other represents CR.sub.5 wherein R.sub.5 is one of the values for R.sub.3 or R.sub.5 is the bond to the NHCO group; or a pharmaceutically acceptable salt thereof, which compounds possess antihypertensive activity while exhibiting reduced CNS depressant properties. Also disclosed are processes for preparing the compounds and pharmaceutical compositions containing them.

Growing community of inventors

Wokingham, United Kingdom

Janet C White