Chiron Corporation

Cetus Corporation

Cetus Oncology Corporation

Janelle N Van Arsdell

Martha B Ladner

Alice M Wang

Ernest S Kawasaki

Mazie Yee Coyne

Kirston E Koths

Robert F Halenbeck

George A Martin

Peter Ralph

David F Mark

Abla A Creasey

Leo S Lin

Mary Kim Warren

Mary K Warren

Ernest S Kaswasaki

Mazie Y Coyne

A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both &ldquo;long&rdquo; and &ldquo;short&rdquo; forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.

DNA encoding N&nabla;2 CSF-1 (short form) and carboxy truncated fragment thereof

A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both 'long' and 'short' forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.

DNA encoding NV2 (long form) and carboxy truncated fragments thereof

A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein. Both 'long' and 'short' forms of this protein and muteins corresponding to the cDNA-encoded forms are disclosed.

N.gradient.2 CSF-1 (short form) and carboxy truncated fragments thereof

A colony stimulating factor. CSF-1, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein.

Recombinant colony stimulating factor-1

A colony stimulating factor, CSF-1, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein.

DNA encoding for CSF-1 and accompanying recombinant systems

Human tumor necrosis factor (TNF) has been prepared using recombinant methods. A human promyelocytic leukemia cell line has been induced using an improved induction procedure, and the TNF purified to homogeneity. Methods, vectors, and cells useful in obtaining human TNF in practical amounts are disclosed. Muteins having N-terminal deletions, which muteins have superior biological activity, are also disclosed.

Human tumor necrosis factor

Human Tumor necrosis factor (TNF) has been prepared using recombinant methods. A human promyelocytic leukemia cell line has been induced using an improved induction procedure, and the TNF purified to homogeneity. Methods, vectors, and cells useful in obtaining human TNF in practical amounts are disclosed. Muteins having N-terminal deletions, which muteins have superior biological activity, are also disclosed.

Growing community of inventors

Oakland, CA, United States of America

Janelle N Van Arsdell