Entasis Therapeutics, Inc.

Janelle Comita-Prevoir

Thomas Francois Durand-Reville

Satenig Guler

Ruben Alberto Tommasi

Neil Bifulco

Hoan Huynh

Bolin Geng

Xiaoyun Wu

Brendan Chen

Shanta Bist

Hui Xiong

Liang Zhao

Jan Romero

Jing Zhang

Ye Wu

Daemian Dussault

Jeroen Cunera Verheijen

Frank Wu

Mark Sylvester

Helen McGuire

Helen Mcguire

John O'Donnell

Lise Gauthier

Camilo Velez-Vega

Gregory S Basarab

Bill Moss

Provided herein are antibacterial compounds represented by Formula I, or a pharmaceutically acceptable salt thereof, wherein X, Y, R, R, and Rare as defined herein. Also provided are pharmaceutical compositions comprising the compounds of Formula I. 

Compounds and methods for treating bacterial infections

The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts are useful in combination with beta-lactam antibiotics, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of R, R, R, R, Rand Rare described herein. 

Beta-lactamase inhibitor compounds

The present invention is directed to compounds which are beta-lacatamase inhibitors. The compounds and their pharmaceutically acceptable salts, are useful in combination with beta-lactam antibiotics, or alone, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to formula (Ia): or a pharmaceutically acceptable salt thereof, wherein the values of R, R, Rand Rare described herein.

&#x3b2;-lactamase inhibitor compounds

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Northborough, MA, United States of America

Janelle Comita-Prevoir