Ironwood Pharmaceuticals, Inc.

Novabay Pharmaceuticals, Inc.

Jane Yang

Kevin Sprott

Ara Mermerian

Timothy Claude Barden

Ramin Najafi

Mansour Bassiri

Lu Wang

John Jeffrey Talley

Mark G Currie

G Todd Milne

James Philip Pearson

Charles Kim

Craig N Zimmerman

Xiang Y Yu

Barbara B Chen

Angelika Fretzen

Brian Cali

Colleen Hudson

James Jia

Yueh-Tyng Chien

Bo Peng

Wayne Schairer

Wilmin Bartolini

Regina Lundrigan

Regina Lundigran

The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.

FAAH inhibitors

Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole.

Indole compounds

Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.

Useful indole compounds

The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This specification also describes methods of use for the new compounds and compositions. The specification further describes methods for preparing these compounds.

N,N-dihalogenated amino acids and derivatives

Described herein is a physiologically-balanced, acidic solution. Typically the solution is prepared by a chemical reactions or by the electrolysis of a solution comprising a mixture of an inorganic salt to form a physiologically balanced solution. This invention also relates to methods for use of the solutions, including a specialized bandage which may be used in combination with the solutions, or optionally with other topically applied materials. A mixture of inorganic salts and, optionally minerals, is used in order to mimic the electrolyte concentration and mixture of body fluid in an isotonic state. The solution typically comprises of one halide salt of lithium, sodium, potassium, calcium, and other cations. Typically the halide is fluoride, chloride, bromide, or iodide, and most typically chloride. A typical electrolyzed solution of the present invention has a pH within the range of about 2 to about 5, an oxidation reduction potential within the range of about +600 mV to about +1200 mV, and hypohalous acid concentration in the range of about 10 ppm to about 200 ppm. The solution has bactericidal, fungicidal, and sporicidal properties. The composition of the invention is nontoxic and has antibacterial properties, and is useful in any application in which antimicrobial properties are desirable.

Physiologically balanced, ionized, acidic solution and methodology for use in wound healing

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Emeryville, CA, United States of America

Jane Yang