Baxter International Inc.

Baxter Healthcare Sa

University of Nebraska

Jane Werling

Mark Joseph Doty

James E Kipp

Barrett E Rabinow

Christine L Rebbeck

Joseph Chung Tak Wong

Mahesh V Chaubal

Howard E Gendelman

Sarah Elizabeth Lee

Shawn F Bairstow

Sean Brynjelsen

Arnaud Beduneau

Rajaram Sriram

Barrett Rabinow

Mahesh Chaubal

The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises a surfactant having formula I, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm: 

Compositions and methods for drug delivery

The present disclosure is directed to surface-modified particles and to methods of making and using the same. The surface-modified particles comprise a particle core and a coating associated with the particle core, wherein the particle core comprises an active agent, the coating comprises an opsonin, and the surface-modified particle has an average size from about 1 nm to about 2,000 nm.

The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the antineoplastic agent in an aqueous medium to form a pre-suspension followed by homogenization. Surfactants with phospholipids conjugated with a water soluble or hydrophilic polymer such as PEG are used as coating for the particles. The particles produced generally have an average particle size of less than about 1000 nm and are not rapidly soluble.

Method for preparing submicron particles of antineoplastic agents

The present invention provides a polymorphic form of itraconazole.

Polymorphic form of itraconazole

The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.

Method for preparing submicron suspensions with polymorph control

Method for preparing submicron particle suspensions

Growing community of inventors

Arlington Heights, IL, United States of America

Jane Werling