Turning Point Therapeutics, Inc.

Senomyx, Inc.

Firmenich Incorporated

Tp Therapeutics, Inc.

Seaomyx, Inc.

Jane Ung

Jingrong Jean Cui

Evan W Rogers

Dayong Zhai

Wei Deng

Andrew P Patron

Chad Priest

Alain Noncovich

Han Zhang

Jeffrey Whitten

Wen Zhao

Donald Karanewsky

Jing Liu

Brant Clayton Boren

Yishan Li

Jeffrey Robert Hammaker

Rachel Kimmich

Zhongdong Huang

Xin Zhang

Volodymyr Chumakov

Lyudmyla Chumakova

Catherine Tachdjian

Joseph R Fotsing

Timothy Davis

Vivian Nguyen

Donald S Karanewsky

The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSFR, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.

Macrocyclic compounds and uses thereof

The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer.

Macrocycles for use in treating disease

The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.

The present disclosure relates to certain macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat disease, such as cancer.

Macrocyclic compounds for treating disease

The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations. 

Compounds useful as modulators of TRPM8

The present disclosure relates to certain chiral diaryl macrocyclic derivatives, of the formula I: pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Chiral diaryl macrocycles as modulators of protein kinases

The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations. 

The present disclosure relates to certain macrocyclic kinase inhibitors, pharmaceutical compositions containing the same, and methods of using the same to treat disease.

Macrocycle kinase inhibitors

Provided herein are compounds which are useful as cooling sensation compounds.

The present disclosure relates to certain chiral diaryl macrocyclic derivatives of the formula I pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Growing community of inventors

San Diego, CA, United States of America

Jane Ung