Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Jane S C Tsai

Mitali Ghoshal

Eric R Diebold

Gerald F Sigler

Allan R Dorn

David Zhi Deng

Robert Sundoro Wu

Stephen S Vitone

Min Li

Shaker Rashid

Yifei Wu

The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.

Electrochemical affinity biosensor system and methods

A water-soluble reference standard is useful for immunoassays of a lipophilic drugs. The reference standard is a compound of formula (I):G-(L)&#x2014;Y;&#x2003;&#x2003;(I)where G is a lipophilic drug; L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms; n is 0 or 1; and Y is a water-solubilizing group such as &#x2014;SO, &#x2014;NR&#x2014;SO, &#x2014;P(&#x2550;O)(OH)(O), or &#x2014;O&#x2014;P(&#x2550;O)(OH)(O); where R is H or an alkyl group of 1 to 10 carbon atoms.

Water-soluble derivatives of lipophilic drugs

Tricyclic antidepressant derivatives and immunoassay

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Indianapolis, IN, United States of America

Jane S C Tsai