Other

Colgate Palmolive Company

Errico, Joseph P.

Jane Ong

Joseph P Errico

Benjamin Mugrage

Pam Wines

Ignatius Turchi

Matthew Sills

John Allocco

James G Masters

Donghui Wu

Chi-Yuan Cheng

Long Pan

Tatiana Brinzari

Margarita Bastos

Harsh Mahendra Trivedi

Laurence Du-Thumm

Shujiang Cheng

Zeenat F Nabi

Qiang Wu

Halyna Siomyk

Zeenat Nabi

Laurence D Du-Thumm

Personal care compositions including a naringin:zinc complex and methods for preparing and using the same are provided. The personal care compositions may include a carrier and a naringin:zinc complex having a 2:1 naringin to zinc molar ratio.

Personal care compositions including naringin:zinc complexes and methods for the same

Disclosed herein are oral care compositions comprising naringin:Zinc complexes having a 2:1 naringin to zinc molar ratio. Methods of making and using the compositions are also provided.

Oral care compositions and methods of use

Provided is a method of treating a proliferative disease, condition, or disorder in a subject by administering a combination of an inhibitor of p53 and MDM2 binding and an EGFR inhibitor. Various embodiments of the disclosed methods provide a synergistic anti-proliferative or anti-apoptotic effect compared to administration of one agent alone.

Combination therapy with MDM2 and EFGR inhibitors

Provided herein are compounds having anti-proliferative effect. Also provided are compounds that can modulate the activity of multi-domain proteins comprising a dimerization arm and interdomain tether, such as EGFR, where an untethered, extended conformation is the active state and a tethered conformation is the inactive state, resulting in an autoinhibited configuration. Also provided are methods and pharmacophores for identifying such compounds. Other aspects provide methods or therapeutic treatment for proliferative diseases, disorders, or conditions, such as those associated with EGFR.

Methods of targeted drug development

Methods and compositions of targeted drug development

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Franklin Park, NJ, United States of America

Jane Ong