Janssen Pharmaceutica Nv

Darwin Discovery Limited

Chirotech Technology Limited

Medeva Europe Limited

Jane Marie Paul

Gerard Andrew Potter

Raymond McCague

Martin Edward Fox

Ulrich Conrad Dyer

Nicholas Bernard Johnson

Christopher Palmer

David Andrew Chaplin

A process for the asymmetric transformation of a racemic compound of formula (I) wherein R is H or a alkyl group having up to 20 carbon atoms, R is H, or an alkyl, aryl, alkaryl or aralkyl group having up to 20 carbon atoms, and X is H, a halogen atom, tert-butyl, or any other removable substituent, comprises reaction of racemic compound (I) with an enantiomerically-enriched acid HY*, wherein Y* is a chiral group, to form a diastereomeric salt of compound (I) having Y* as a counterion. The salt obtained can then be reduced to give enantiomerically-enriched galanthamine, or a derivative thereof.

Optical resolution of narwedine-type compounds

A process for the preparation of an enantioenriched sulfone of formula (1), which comprises asymmetric hydrogenation of vinyl sulfone of formula (2)

Asymmetric hydrogenation of vinyl sulfones

7-amino-2-heptenoates and their use in the preparation of methylphenidate

Process for preparing galanthamine derivatives by asymmetric reduction

Racemisation of amines

Growing community of inventors

Cambridge, United Kingdom

Jane Marie Paul