Other

Defyrus, Inc.

Baksh, Dolores

Davies, John E.

Ennis, Jane

Gomez-aristiz-abal, Alejandro

Sarugaser, Rahul

Gomez-artistizabal, Alejandro

Jane Ennis

John Edward Davies

Dolores Baksh

Rahul Sarugaser

Alejandro Gomez-Aristiz-Abal

Jeffrey D Turner

John E Davies

Alejandro Gomez-Artistizabal

Described herein is a method for modulating an immune reaction between lymphocytes and a body recognized by the lymphocytes as foreign. The method exploits the immunomodulating activity of a new class of progenitor cells termed HUCPVCs derived from the perivascular region of human umbilical cord. The method can also emply soluble factors exuded by cultured HUCPVCs. The method is useful to treat immune disorders including graft versus host disease, autoimmune disorders, and the like.

Immune privileged and modulatory progenitor cells

Viable progenitor cells are extracted from frozen umbilical cord tissue. In embodiments, the umbilical cord tissue is a blood vessel bearing perivascular Wharton's jelly, and the extracted progenitor cells are HUCPVCs.

Viable cells from frozen umbilical cord tissue

The invention provides compositions and methods for the prophylaxis or treatment of diseases or disorders in a subject (e.g., a mammal, such as a human) including, e.g., diseases or disorders caused by biological agents, autoimmune diseases, and cancer. The compositions include a delivery vector (e.g., a viral vector, such as an Ad5 vector) encoding an interferon (e.g., IFN-&#x3b1;), and are provided to the subject by, e.g., intranasal or pulmonary administration.

Administration of interferon for prophylaxis against or treatment of pathogenic infection

Described herein is a method for modulating an immune reaction between lymphocytes and a body recognized by the lymphocytes as foreign. The method exploits the immunomodulating activity of a new class of progenitor cells termed HUCPVCs derived from the perivascular region of human umbilical cord. The method can also employ soluble factors exuded by cultured HUCPVCs. The method is useful to treat immune disorders including graft versus host disease, autoimmune disorders, and the like.

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Toronto, Canada

Jane Ennis