Becton Dickinson and Company Limited

Jane C Graper

Erwin A Vogler

Thomas A Shepard

Joel L Williams

Garry R Harper

Abraham Schwartz

Nicholas A Grippi

Yelena G Tropsha

David Alan Martin

Jamshed B Ghandhi

Kevin D Mar

The present invention is a non-ideal barrier coating composition and the method for applying the coating composition to substrates. The non-ideal barrier coating is useful for providing an effective barrier against gas permeability in containers and for extending shelf-life of containers, especially plastic evacuated blood collection devices.

Non-ideal barrier coating architecture and process for applying the same

Gel formulations including a polydimethylsiloxane-polyethyleneoxide copolymer gelled with dibenzylidine sorbitol in the presence of water or alcohol, The gel formulations are useful for facilitating the separation of blood serum or plasma from the cellular portion of blood or as a thermoreversible shear sensitive substance.

Blood compatible, shear sensitive gels

A blood collection assembly with gel formulations including a polydimethylsiloxane-polyethyleneoxide copolymer gelled with dibenzylidine sorbitol in the presence of water or alcohol. The gel formulations are useful for facilitating the separation of blood serum or plasma from the cellular portion of blood or as a thermoreversible shear sensitive substance.

Blood collection assembly with blood compatible, shear sensitive gels

Method for forming blood compatible, shear sensitive gel formulations including a polydimethylsiloxane-polyethyleneoxide copolymer gelled with dibenzylidine sorbitol in the presence of water or alcohol. The gel formulations are useful for facilitating the separation of blood serum or plasma from the cellular portion of blood or as a thermoreversible shear sensitive substance.

Method for forming blood compatible, shear sensitive gels

Gel formulations including a polydimethylsiloxane-polyethyleneoxide copolymer gelled with dibenzylidine sorbitol in the presence of water or alcohol. The gel formulations are useful for facilitating the separation of blood serum or plasma from the cellular portion of blood or as a thermoreversible shear sensitive substance.

A blood collection assembly includes a container, optionally covered by a puncturable septum and evacuated. A clotting enhancer in the container activates both the intrinsic and extrinsic coagulation pathways. The invention includes a method to make the clotting enhancer.

Method for preparing a dual pathway clotting enhancer for blood

A blood collection assembly includes a tube, which may be glass or plastic, and a plastic insert therein. The insert has been plasma-treated to change the surface chemistry and render it clot activating.

Blood collection assembly including clot-accelerating plastic insert

A blood collection assembly includes a container, optionally covered by a puncturable septum and evacuated. A clotting enhancer in the container activates both the intrinsic and extrinsic coagulation pathways.

Dual pathway clotting enhancer for blood collection tube

An evacuated blood collection assembly includes a plastic container having a plasma-treated inside wall surface and an open end covered by a puncturable septum. The inside wall surface may also be abraded to increase surface area. The invention included a method to make the assembly.

Vacuum actuated blood collection assembly including tube of

A blood collection container is coated on its inside wall with a unitarily immobilized clotting activator. The activator may be applied to the surface by an adhesive or by rendering the inside wall surface sticky with a solvent and partially absorbing the activator into the sticky surface.

Tube having unitary blood coagulation activator and method for its

A process for coating polymer particles with an additive includes preparing a liquid composition comprising one or more desired additives and a gelling agent in an oil. The composition is coated onto the polymer particle by any convenient procedure. On cooling the coated particle below the gelling point, the composition gels providing a polymer particle having a uniform coating of the additives which is suitable for direct introduction into a mold.

Process for uniform coating of polymer particles with an additive

A method to impart increased lubricity to the surface of a polymeric substrate includes contacting the substrate with a solution of a hydrophilic polymer in a solvent and heating the substrate to evaporate the solvent. The substrate retains a coating of the hydrophilic polymer, which, when dry, has about the same lubricity as the uncoated substrate. When wet, the coating becomes significantly more lubricious than when dry. The invention includes articles which have a lubricious surface when wet prepared by the method of the invention.

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Durham, NC, United States of America

Jane C Graper