Ge Healthcare Limited

Jane Brown

Rajiv Bhalla

Magne Solbakken

Matthias Eberhard Glaser

Sajinder Kaur Luthra

Ben Newton

Imtiaz Ahmed Khan

Peter Brian Iveson

Robert James Nairne

Mette Husbyn

Robert James Domett Nairne

Anthony Wilson

Salah Chettibi

Andres Black

James Nairne

Daniel Kramer

Andrew Black

Sajinder Luthra

[F]-fluoralkyl tosylates are useful building block for the radiosynthesis of a number of small molecules. A method of purifying [F]-fluoroalkyl tosylates using an automated radiosynthesis apparatus (e.g. FASTlab module) is described. A method of purifying [F]-fluoroalky tosylates using a FASTlab module that includes a solid phase extraction (SPE) purification system is described.

[object Object]

The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.

Method for the synthesis of 18F-labelled molecules

The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A precursor for the preparation of the imaging agent is also provided by the invention, as well as a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition which comprises fibrosis is provided.

Imaging agents

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Amersham, United Kingdom

Jane Brown