The United States of America As Represented by the Department of Health

The United States of America, As Represented by the Secretary, Department of Health and Human Services

The United States of America As Represented by the Secretary of

University of California

The University of Texas System

Jane B Trepel

Charles E Myers

Farzaneh Pirnia

Wei-Gang Fang

Dvorit Samid

Leonard M Neckers

Edward A Sausville

Len Neckers

Robert J Fletterick

Yeong Sang Kim

Yangmin Ning

Heather A Balsiger

Alexandra Miller

Gregory Curt

Won Ki Kang

Luke Whitesell

Eun Joo Chung

Marc B Cox

Aki Iwai

Johanny Meneses De Leon

The invention provides methods for quickly and easily screening mixed cell samples for a pharmacodynamic effect to a drug or test agent.

Pharmacodynamic assays

Methods of treating various cancers, such as prostatic adenocarcinoma, with inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG Co-A), such as lovastatin, are provided. Dosing ranges, schedules and toxicities are included.

Use of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase as

The instant invention is directed to the use of a pharmaceutical composition containing an effective amount of adenosine or an adenosine analog or derivative as an agent useful in the treatment of hormone-independent cancers, such as prostate cancer. The invention is also directed to diagnostic uses of these compounds to determine effective treatment regimes for specific tumors, a process for screening for new, therapeutically useful analogs of these compounds, and the use of these compounds in facilitating the extraction of intracellular components.

Use of purinergic receptor agonists as antineoplastic agents

The invention provides methods of treating cancer including administering an effective amount of selected terpenes to a mammal having the cancer when the cancer is prostate cancer, colon cancer, astrocytoma, or sarcoma. The terpene is selected from the group consisting of a cyclic monoterpene, a noncyclic monoterpene, a noncyclic sesquiterpene and a noncyclic diterpene. The invention also provides a method of sensitizing a cancer to radiation including administering an effective amount of a terpene to a mammal having the cancer wherein the terpene is selected from the group noted above. Additionally, the invention provides methods of inhibiting the growth of cancer cells including applying an effective amount of a selected terpene to the cancer cells which are cells of prostate cancer, colon cancer, osteosarcoma, or glioblastoma.

Monoterpenes, sesquiterpenes and diterpenes as cancer therapy

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Bethesda, MD, United States of America

Jane B Trepel