Duke University

The Brigham and Women's Hospital, Inc.

Lawrence Livermore National Security, LLC

The Brigham and Woman's Hoospital, Inc.

Jane A Leopold

Amanda Randles

Erik V Mukerjee

Joseph Loscalzo

Bradley Maron

A stent apparatus, system, and method that senses wall shear stress by measuring fluid flow at localized areas within the stent, that processes measured information through an integrated circuit, and selectively sends power to mechanically controllable stent surfaces which results in localized geometric changes. In various embodiments the stent apparatus, system, and method sends data to outside the body in real time.

Preventing stent failure using adaptive shear responsive endovascular implant

Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2D) image data are provided. Data is segmented from 2D images of a sample having a biological structure with fluid flow therethrough. Three-dimensional (3D) geometries are generated from the segmented data, and then a 3D reconstruction of the biological structure is generated from the 3D geometries. This 3D geometric computational analysis tool can be used to evaluate fluid dynamics and hemodynamics in the context of the structure anatomy and geometry.

Methods and systems for generating fluid simulation models

The technology described herein is directed to agents that reduce the level of oxidant-modified ET-B Cys405, Cys403, or Cys402 and the identification and use of such agents for, e.g. to treat hypertension.

Compositions and methods for treating hypertension

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Chestnut Hill, MA, United States of America

Jane A Leopold