Bayer Aktiengesellschaft

J&uuml;rgen Sdebik

Bernd Klinksiek

Venkata-Rangarao Kanikanti

Said Mahiout

Ricarda-Christine Nothelle

Hans-J&uuml;rgen Hamann

The present invention relates to stable quick-release extrudates that contain low-viscosity hydroxypropylcellulose and at least one active ingredient. This invention also relates to a method for preparing said extrudates without the use of solvents as well as to the use of said extrudates in the production of quick-release preparations.

Quick-release extrudates, method for preparing the same and compositions obtained from said extrudates

In the procedure for the production of a formulation of parenterally administrable pharmaceutical preparations, a liposome dispersion is used as a carrier for a pharmaceutical active compound. For the preparation of the liposome dispersion, an aqueous predispersion of one or more amphiphilic substances is fed to a high-pressure homogenizer in which the predispersion is pumped under a pressure from 600 bar to 900 bar through a homogenizer nozzle (,) having a diameter of 0.1 to 0.5 mm. The homogenizer nozzle has an inlet channel (,) and an outlet channel (,) and consists of a hard ceramic plate (,), in which the bore (,) is present, pressed into a steel body (,). The inlet channel (,) and the outlet channel (,) are likewise incorporated into the steel body (,).

Growing community of inventors

Düsseldorf, Germany

Jürgen Sdebik

Growing community of inventors

Düsseldorf, Germany

J&uuml;rgen Sdebik

Jürgen Sdebik