Celanese Ventures Gmbh

Aventis Research & Technologies Gmbh & Co Kg

Axiva Gmbh

J&uuml;rgen Grande

Holger Bengs

Gitte B&ouml;hm

Arnold Schneller

Silke Schuth

Alfred Braunagel

Anette Brunner

Compositions are described, based on starch and/or on modified starch and comprising, as plasticizers, polyhydroxycarboxylic acids derived from aldoses and/or from ketoses, in particular from pentoses and hexoses, or comprising lactones of these acids. The materials can be processed thermoplastically to give shaped articles which are biodegradable and physiologically nonhazardous. They may be used as packaging or casing for food or drink or pharmaceutical products, or also for the controlled release of active substances, or else for producing temporary protective coatings.

Compositions comprising starch and/or modified starch and plasticizers

The present invention relates to a method for preparing smooth-surface spherical microparticles which are completely or partially made of at least one water-insoluble linear polysaccharide. This method involves dissolving the at least one water-insoluble linear polysaccharide in a solvent or a mixture of solvents, introducing the solution into a precipitation agent or a mixture of precipitation agents, optionally cooling the mixture thus obtained, and separating the microparticles thus formed. The precipitation agent used consists of at least one water-soluble cellulose derivative. This invention also relates to microparticles obtained according to this method.

Method for preparing smooth-surface spherical microparticles completely or partially made of at least one water-insoluble linear polysaccharide and microparticles produced according to this method

Microparticles with a uniform spherical shape and a very narrow size distribution are described. They consist wholly or partly of a linear water-insoluble polysaccharide, preferably of 1,4-&agr;-D-polyglucan, and may contain other, in particular biodegradable, polymers and/or active substances. They are suitable inter alia for the controlled delivery of active substances. They are prepared by dissolving 1,4-&agr;-D-polyglucan or the polysaccharide in a solvent, introducing the solution into a precipitant, cooling the mixture and removing the particles formed.

Spherical microparticles containing linear polysaccharides

The present invention relates to a method for the production of small spherical particles consisting totally or partly of at least one water-insoluble linear polysaccharide by dissolving the at least one water-insoluble polysaccharide in a solvent or a solvent mixture, introducing the solution into a precipitating agent or a precipitating agent mixture, optionally cooling the mixture thus obtained and separating the formed small particles, wherein at least one poly alpha D-glucan soluble in hot water is used as auxiliary agent for precipitation. The invention also relates to the particles obtained according to said method.

Method for the production of small spherical particles containing at least one water-insoluble linear polysaccharide

The invention relates to a controlled release tablet which in part or as a whole contains water-insoluble linear polysaccharides, preferably the polysaccharide poly(1,4-&agr;-D-glucan), in the form of microparticles, as retardation material. The tablet is also capable of controllably releasing an active agent.

Slow release tablet prepared from linear water-insoluble polysacchrides

Compositions are described, based on starch and/or on modified starch and comprising, as plasticizers, polyhydroxycarboxylic acids derived from aldoses and/or from ketoses, in particular from pentoses and hexoses, or comprising lactones of these acids such as &dgr;-caprolactone. The materials can be processed thermoplastically to give shaped articles which are biodegradable and physiologically nonhazardous. They may be used as packaging or casing for food or drink or pharmaceutical products, or also for the controlled release of active substances, or else for producing temporary protective coatings.

Compositions containing starch and/or modified starch and plasticisers

The invention relates to a method for the production of spherical microparticles consisting totally or partly of at least one water-insoluble polysaccharide, wherein the at least one water-insoluble polysaccharide is dissolved in a solvent or solvent mixture, the solution thus formed is introduced into a precipitating agent or precipitating agent mixture, the mixture obtained is optionally cooled and the formed microparticles are separated. The invention is characterized in that the water-insoluble polysaccharide is selected from a polyglucan containing branches with a degree of branching higher than zero and no higher than 8% and a mixture of a polyglucan containing branches and a linear polysaccharide, wherein the proportion of polyglucan containing branches in the mixture is at the most 30% by weight in relation to the overall weight of the polysaccharide and the polyglucan.

Method for the production of spherical microparticles consisting totally or partly of at least one water insoluble polyglucan containing branches and microparticles produced according to said method

The present invention relates to a topical preparation containing spherical microparticles as the essential component, wherein the microparticles comprise water-insoluble linear polyglucan.

Cosmetic or medical preparation for topical use

Thermoplastic mixture containing 1,4-&agr;-D-polyglucane, method for making the same and use thereof

Homogeneous mixtures are described and can be processed to give shaped biodegradable and physiologically nonhazardous articles, such as packagings for food or drink or pharmaceutical products, sausage casings and the like. The mixtures comprise dialdehyde starch with a degree of oxidation of greater than 30%, starch which does not exhibit any iodine-starch reaction, and/or modified starch, water and other plasticizers, and also, if desired, other biopolymers and additives.

Growing community of inventors

Bad Soden, Germany

Jürgen Grande

Growing community of inventors

Bad Soden, Germany

J&uuml;rgen Grande

Jürgen Grande