Abbott Laboratories Corporation

Abbott Gmbh & Co Kg

Basf Aktiengesellschaft

J&ouml;rg Rosenberg

J&ouml;rg Breitenbach

Werner Maier

J&uuml;rgen Zeidler

Gunther Berndl

J&ouml;rg Neumann

Bernd Liepold

Ulrich Reinhold

Reinhard Spengler

Bernd Leipold

Christiane Vollgraf

A process for producing solid dosage forms by a) producing a plastic mixture which comprises at least one active ingredient and at least one polymeric binder, and b) shaping the plastic mixture to the solid dosage forms in a molding calender with two counterrotating molding rolls, wherein one molding roll has at least one annular groove running along its periphery and the other molding roll has at least one ring, running along its periphery, of teeth extending radially outward and able to engage in the annular groove is described.

Method of producing solid dosage forms

The invention relates to a process and an apparatus for producing solid dosage forms by molding plastic active ingredient-containing mixtures with use of a continuously operating molding tool with two parts which cooperate to mold the plastic mixture, with at least one part having a plurality of depressions to receive and mold the plastic mixture, wherein one part has at least two groups, which differ in volume and/or shape, of depressions. Dosage forms which differ in shape or size are obtained in one step.

Method and device for producing different solid dosage forms

A process for producing solid dosage forms by forming a plastic mixture of at least one polymeric binder, at least one active ingredient and, where appropriate, conventional additives, and shaping the plastic mixture to the solid dosage forms using a mold, wherein an agent which modifies the surface properties is applied in finely divided form to the surface of the plastic, mixture during the shaping is described. The agent which modifies the surface properties is preferably a surfactant, a lipophilic compound, an antioxidant, a coloring agent or an agent with antistatic effect and/or lubricant effect.

Method for producing solid dosing forms

The present invention relates to mechanically stable pharmaceutical presentations for oral administration, comprising in addition to one or more active ingredients and at least one melt-processable matrix-forming excipient more than 10 and up to 40% by weight of a surface-active substance with an HLB of from 2 to 18, which is liquid at 20&deg; C. or has a drop point in the range from 20 to 50&deg; C.

Mechanically stable pharmaceutical presentations form containing liquid or semisolid surface-active substances

Solvent-free noncrystalline bioactive substances are prepared from the corresponding crystalline bioactive substances in an extruder by melting the substances in the extruder under reduced pressure and in the absence of auxiliaries, cooling and comminuting.

Method for producing solvent-free noncrystalline biologically active substances

Solid, elongate dosage forms ( ) with a long axis ( ) and with a length (L) which is defined by projection of the ends ( ) of the dosage form to the long axis, where a cross-sectional area ( ) oriented perpendicular to the long axis ( ) has an area which is variable along the long axis ( ) and increases from a cross-sectional area ( ) which is located between the ends ( ) and has a minimal area essentially continuously toward the two ends ( ) up to in each case a cross-sectional area ( and respectively) with a maximal area, wherein the distance of the maximal cross-sectional area ( ) which is located near one end ( ) from the maximal cross-sectional area ( ) which is located near the other end ( ) is, projected on the long axis ( ), more than half the length (L) of the dosage form ( ), are described.

Cleavable solid dosage forms and method for the production thereof

A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm,.

Growing community of inventors

Ellerstadt, Germany

Jörg Rosenberg

Growing community of inventors

Ellerstadt, Germany

J&ouml;rg Rosenberg

Jörg Rosenberg