Other

J&aacute;nos Wellmann

Gyula Simig

Andr&aacute;s Egyed

K&aacute;roly Tihanyi

Katalin Pallagi

J&oacute;zsef Bark&oacute;czy

Istv&aacute;n Gacs&aacute;lyi

Gy&oacute;rgy L&eacute;vay

Iv&aacute;n Jak&oacute;czi

L&aacute;szl&oacute; Posz&aacute;v&aacute;cz

G&aacute;bor N&eacute;meth

D&aacute;niel B&oacute;zsing

Ildik&oacute; R&aacute;tzn&eacute; Simonek

J&oacute;zsef Reiter

Katalin Ivanicsn&eacute; Megyeri

S&aacute;ndor Drabant

G&aacute;bor Berecz

Szabolcs Kert&eacute;sz

Anik&oacute; Mikl&oacute;sn&eacute; Kov&aacute;cs

M&aacute;ria Sz&eacute;cseyn&eacute; Heged&uuml;s

Ildik&oacute; Nagyn&eacute; Gy&ouml;n&ouml;s

G&aacute;bor Sz&eacute;n&aacute;si

&Eacute;va Schmidt

P&eacute;ter Trinka

Margit Cs&ouml;rg&ouml;

Piperazinylalkylthiopyrimidine derivatives of formula (I), a process for preparing them, and pharmaceutical compositions containing them as active substances. The compounds are useful for the treatment of central nervous system disorders, especially anxiety.

Piperazinylalkylthiopyrimidine derivatives, pharmaceutical compositions containing the same, and a process for the preparation of the active substance

The invention refers to novel 2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives of formula (I) having an influence on the heart and the central nervous system, furthermore pharmaceutical compositions containing the above derivatives, and a process for the preparations of the novel compounds. In formula (I) R,represents a hydrogen atom, a C,alkyl group of a phenyl group optionally substituted by 1 to 3 substituents selected from the group defined in the application, Z stands for a hydrogen atom of a C,alkoxy group, R,means a group of the formula Alk&mdash;NR,R,wherein Alk is a C,straight of branched chain alkylene group, R,and R,represent, independently, a hydrogen atom, a C,alkenyl group, a C,alkyl group optionally substituted by a substituent selected from the group defined in the application or R,and R,form together with the adjacent nitrogen atom and optionally with one or more further nitrogen and/or oxygen and/or sulfur atom(s) a 5- to 10-membered saturated heterocyclic group, optionally substituted, one of R,and R,is an amino group, while the other stands for an amino group of a 5- to 10-membered saturated heterocyclic group containing one or more nitrogen and/or oxygen and/or sulfur atom(s) and being linked through its nitrogen atom, said heterocyclic group being optionally substituted or the latter one of R,and R,means a group of formula &mdash;SR wherein R represents a C,alkyl group, a C,alkenyl group or a C,alkinyl group, wherein the alkyl group is optionally substituted by a phenyl group of a halophenyl group, and optionally one or both amino group(s) is/are substituted by 1 of 2 substituent(s) selected from the group consisting of a C,alkyl group, a C,alkenyl group, a phenyl(C,alkyl) group or a halophenyl-(C,alkyl) group.

2-(1,2,4-triazole-1-yl)-1,3,4-thiadiazole derivatives having an effect on the C.N.S. and the heart

Growing community of inventors

Budapest, Hungary

János Wellmann

Growing community of inventors

Budapest, Hungary

J&aacute;nos Wellmann

János Wellmann