Supernus Pharmaceuticals, Inc.

Convergene, LLC

Dogwood Pharmaceuticals, Inc.

Other

Janak Khimchand Padia

Jeffrey William Strovel

Hariprasad Vankayalapati

Wieslaw Marek Cholody

Yi Zang

Makoto Yoshioka

Zoe Ohler

Sheela Chellappan

Karina Zuck

Jeffrey W H Watthey

Gene Ohler

Norman E Ohler

A compound of Formula I includes a stereoisomer thereof and/or a salt thereof; wherein Ris a substituted alkane group, a heterocylic group, or a pyridine group; X is hydrogen, a halogen, an amino acid residue, a substituted amino acid residue, an alkyl group, or an ester. Such compounds may be used in pharmaceutical compositions and for the treatment of central nervous system (CNS) disorders:

Derivatives of substituted morpholines and uses thereof

A compound of Formula I includes a stereoisomer thereof and/or a salt thereof; wherein Ris a substituted alkane group, a heterocylic group, or a pyridine group; X is hydrogen, a halogen, an amino acid residue, a substituted amino acid residue, an alkyl group, or an ester. Such compounds may be used in pharmaceutical compositions and for the treatment of central nervous system (CNS) disorders: 

The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.

Methods and compositions for inhibition of bromodomain-containing proteins

Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/&#x3b2;-catenin signaling pathway, and serve to reduce &#x3b2;-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof

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Germantown, MD, United States of America

Janak Khimchand Padia