Warner-lambert Company

Janak Khimchand Padia

Bharat Kalidas Trivedi

Bruce D Roth

David Christopher Horwell

William Howard Roark

Jurgen Kleinschroth

Edward Roberts

Ann Holmes

Gary Louis Bolton

David Charles Rees

Bradley Dean Tait

Reginald S Richardson

Joseph Anthony Cornicelli

John Edward Strode

Novel quinazolinone derivatives with good binding affinity for the CCK-A and CCK-B receptors, pharmaceutical compositions containing them and methods of using them are taught. The compounds are useful agents to suppress appetite, reduce gastric acid secretion, and the like.

Heterocycles as cholecystokinin (CCK) ligands

Pyrazolone derivatives of Formula I or a pharmaceutically acceptable salt thereof are MCP-1 antagonists and are thus useful in the treatment of inflammatory diseases or conditions, atherosclerosis, restenosis, and immune disorders such as arthritis and transplant rejection ##STR1## where: R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 can be independently H,

Pyrazolone derivatives as MCP-1 antagonists

Method for treating and preventing inflammation and atherosclerosis

Benzimidazole compounds useful for the treatment of inflammatory

Novel quinazolinone derivatives with good binding affinity for the CCK-A and CCK-B receptors, pharmaceutical compositions containing them, methods of using them and a novel process for their preparation are taught. The compounds are useful agents to suppress appetite, reduce gastric acid secretion, and the like.

Quinazolinone derivatives as cholecystokinin (CCK) ligands

Novel cholecystokinin antagonists useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with use of nicotine, diazepam, alcohol, cocaine, coffee, or opioids. The compounds of the invention are also useful in treating and/or preventing panic. Also disclosed are pharmaceutical compositions and methods of treatment using the antagonists as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds in diagnostic compositions.

Cholecystokinin antagonists, their preparation and therapeutic use

Quinazolinone derivatives as cholyecystokinin (CCK) ligands

Novel phosphorus containing compounds are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.

Phosphorus containing compounds as antihypercholesterolemic and

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Ypsilanti, MI, United States of America

Janak Khimchand Padia